Measurements of some spectrophotometric parameters of curcumin in 12 polar and nonpolar organic solvents

Jasim, Fadhil; Ali, Fatima

doi:10.1016/0026-265x(89)90024-6

Cited by 34 publications

(12 citation statements)

References 2 publications

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“…On the contrary, curcumin is insoluble in aqueous media at neutral pH and, as a result, exhibits low absorbance. In agreement with previous studies,20–22 a UV-Vis absorbance spectrum of curcumin in DMSO gave rise to a single major peak centered at 430 nm while the corresponding spectrum of free curcumin in PBS displayed far less absorbance (Figure 3). In comparison, the spectrum of curcumin-ND in PBS was of similar intensity to that of free curcumin in DMSO, indicating solubilization of curcumin.…”

Section: Resultssupporting

confidence: 92%

Curcumin nanodisks: formulation and characterization

Ghosh

Singh

et al. 2011

Nanomedicine: Nanotechnology, Biology and Medicine

134

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Nanodisks (ND) are nanoscale, disk-shaped phospholipid bilayers whose edge is stabilized by apolipoproteins. In the present study, ND were formulated with the bioactive polyphenol, curcumin, at a 6:1 phospholipid:curcumin molar ratio. Atomic force microscopy revealed that curcumin-ND are particles with diameters <50 nm and thickness of a phospholipid bilayer. When formulated in ND, curcumin is water-soluble and gives rise to a characteristic absorbance spectrum with a peak centered at 420 nm. Fluorescence spectroscopy of curcumin-ND provided evidence of self-quenching. Incubation of curcumin-ND with empty-ND relieved the selfquenching, indicating redistribution of curcumin between curcumin loaded-and empty-ND. In HepG2 cells, curcumin-ND mediated enhanced cell growth inhibition compared to free curcumin. In a cell culture model of mantle cell lymphoma, curcumin-ND were a more potent inducer of apoptosis than free curcumin. The nanoscale size of the complexes, combined with their ability to solubilize curcumin, indicates ND may have in vivo therapeutic applications.

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Section: Resultssupporting

confidence: 92%

Curcumin nanodisks: formulation and characterization

Ghosh

Singh

et al. 2011

Nanomedicine: Nanotechnology, Biology and Medicine

134

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“…Curcumin, 1,7-bis(4-hydroxy-3-methoxy-phenyl)-1,6-heptadiene-3,5-dione, turmeric yellow, scheme 1, is an orange crystalline compound (1) which is insoluble in water (2) but soluble in some organic solvents and finds many applications in food and dye industries and agriculture. The annual world consumption of this natural dye, which is obtained from the plant Curcuma Longa, is around 200000 tons.…”

Section: Introductionmentioning

confidence: 99%

Some observations on the thermal behaviour of curcumin under air and argon atmospheres

Jasim

Talib

1992

Journal of Thermal Analysis

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The TG, DTG and DTA curves of curcumin(I) have been recorded in static air and inert dynamic argon atmosphere over the range between ambient temperature and 600~176 using a Netzsch thermal analyser STA 429. Careful examination of these curves reveals appreciable differences in the behaviour of I under either atmospheres, which are easily recognized by comparing the profiles of their thermal curves, particularly in the melting point, thermal stability of intermediates, percent weight loss and exothermieity of the chemical processes. Gaschromatographic analysis of volatile pyrolysates trapped during thermal analysis indicates the formation of (CH3)2CO, CH3COH and C6HsOCH2COOH (phenyl oxyacetie acid). However, in static air CO2 and H20 were identified as well. X-ray diffractometry reveals the formation of amorphous carbon as a final product in argon and a mixture of amorphous carbon and graphite in air. It seems that the relatively high mass of argon plays an important role in the reactions and stability of intermediates. In either atmospheres curcumin is thermally stable up to 249~ with m.p. of 176.4~176The unique shape of the DTA curve of I could be used for its identification.

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“…When xylene was used as a solvent for curcumin or its metal complexes, the spectra obtained exhibited more than one shoulder, (Figure 2), indicating either the presence of more than one isomer in the ground state [16,22], or that different types of bonds exist between solute and solvent molecules. These bonds being less stable in non-polar than in polar solvents [26]. …”

Section: Uv/vis Spectra Of Curcumin and Curcumin Derivatives In Variomentioning

confidence: 99%

“…To evaluate the contributions of these two factors we plotted Stokes' shift against two parameters, namely orientation polarity (Δf) and solvent polarity parameter (E T 30) [6,26]. Δf was estimated using Lippert equation derivative below:…”

Section: Accepted Manuscriptmentioning

confidence: 99%