Measurements of the parapapillary atrophy zones in en face optical coherence tomography images

Miki, Atsuya; Ikuno, Yasushi; Weinreb, Robert N.; Yokoyama, Jun; Asai, Tomoko; Usui, Shinichi; Nishida, Kohji

doi:10.1371/journal.pone.0175347

Cited by 26 publications

(30 citation statements)

References 31 publications

(65 reference statements)

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“…But previous investigations have also revealed that PPA +BM was more significantly correlated with glaucoma [1,2,4,43]. Teng et al [44] described that high IOP in patients with glaucoma may cause obstruction of the parapapillary choriocapillaris and, in turn, may lead to the degeneration of the RPE and adjacent cells.…”

Section: Discussionmentioning

confidence: 98%

“…In terms of β-zone PPA, PPA +BM has been reported to be associated with older age or myopia [3][4][5].…”

Section: Discussionmentioning

confidence: 99%

“…Several clinic-based studies have shown that PPA +BM was mostly associated with glaucoma, older age, and myopia. However, PPA -BM was associated with a longer axial length but not with glaucoma [2][3][4][5]. A previous study showed that optic nerve head (ONH) tilt was associated with PPA +BM and PPA -BM widths, which suggested that the microstructure of PPA might reflect the myopic remodeling of the ONH [6].…”

Section: Introductionmentioning

confidence: 96%

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Association of macular thickness with parapapillary atrophy in myopic eyes

Piao

Guo

et al. 2020

Preprint

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KEYWORDSmacular thickness, axial length, myopia, β-parapapillary atrophy with Bruch's membrane, β-parapapillary atrophy without Bruch's membrane Abstract Background: To investigate whether macular structure could be affected by axial elongation and to determine the association between macular intraretinal thickness and the microstructure of β-zone parapapillary atrophy (PPA) in myopic eyes. Methods:The study recruited 113 healthy myopic subjects (113 eyes). Images of the macula, subfoveal choroid, and optic nerve head were acquired using spectral-domain optical coherence tomography (SD-OCT). An automatic segmentation algorithm was used to segment the macular images into 7 intraretinal layers. PPA widths with and without Bruch's membrane (PPA +BM and PPA -BM , respectively) were evaluated. Linear regression analysis was performed to evaluate the association between macular intraretinal thickness and axial length and the microstructure of PPA. Results: An increase in axial length was associated with a decrease in whole macular thickness of the peripheral region and an increase in whole macular thickness of the central region. Thickness alterations of the macular intraretinal layers were most apparent in the peripheral region. A significant correlation was found between PPA -BM width and macular intraretinal layer thickness, whereas no significant correlation was found between PPA +BM width and macular intraretinal layer thickness. Moreover, both PPA +BM and PPA -BM widths significantly correlated with subfoveal choroidal thickness. Conclusions: Macular intraretinal layer thickness may be affected by PPA -BM width. These findings indicate that the microstructure of PPA should be considered when evaluating the macula in patient with myopia and glaucoma.

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Section: Discussionmentioning

confidence: 98%

“…In terms of β-zone PPA, PPA +BM has been reported to be associated with older age or myopia [3][4][5].…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

See 1 more Smart Citation

Association of macular thickness with parapapillary atrophy in myopic eyes

Piao

Guo

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…In terms of β-zone PPA, PPA +BM has been reported to be associated with older age or myopia [3][4][5]. But previous investigations have also revealed that PPA +BM was more significantly correlated with glaucoma [1,2,4,43]. Teng et al [44] described that high IOP in patients with glaucoma may cause obstruction of the parapapillary choriocapillaris and, in turn, may lead to the degeneration of the RPE and adjacent cells.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

Association of macular thickness with parapapillary atrophy in myopic eyes

Piao

Guo

et al. 2020

BMC Ophthalmol

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Background: To investigate whether macular structure could be affected by axial elongation and to determine the association between macular intraretinal thickness and the microstructure of β-zone parapapillary atrophy (PPA) in myopic eyes. Methods: The study recruited 113 healthy myopic subjects (113 eyes). Images of the macula, subfoveal choroid, and optic nerve head were acquired using spectral-domain optical coherence tomography (SD-OCT). An automatic segmentation algorithm was used to segment the macular images into 7 intraretinal layers. PPA widths with and without Bruch's membrane (PPA +BM and PPA-BM , respectively) were evaluated. Linear regression analysis was performed to evaluate the association between macular intraretinal thickness and axial length and the microstructure of PPA. Results: An increase in axial length was associated with a decrease in whole macular thickness of the peripheral region and an increase in whole macular thickness of the central region. Thickness alterations of the macular intraretinal layers were most apparent in the peripheral region. A significant correlation was found between PPA-BM width and macular intraretinal layer thickness, whereas no significant correlation was found between PPA +BM width and macular intraretinal layer thickness. Moreover, both PPA +BM and PPA-BM widths significantly correlated with subfoveal choroidal thickness. Conclusions: Macular intraretinal layer thickness may be affected by PPA-BM width. These findings indicate that the microstructure of PPA should be considered when evaluating the macula in patient with myopia and glaucoma.

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