Measures of Adiposity and Risk of Breast Cancer in Older Postmenopausal Women

Krebs, Erin E.; Taylor, Brent C.; Cauley, Jane A.; Stone, Katie L.; Bowman, Paula J.; Ensrud, Kristine E.

doi:10.1111/j.1532-5415.2005.00541.x

Cited by 45 publications

(38 citation statements)

References 48 publications

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“…Specifically, breast cancer rates were 49% higher for women in the uppermost quartile of weight (hazard ratio (HR) = 1.49, 95% CI = 1.05-2.10) and 58% higher for women in the top quartile of percentage of body fat (HR = 1.58, 95% CI = 1.11-2.23) than for women in the lowest quartile of each measure. The associations between adiposity measures and breast cancer rates were not altered when the analyses were limited to very elderly women (> or = 70) [25]. Furthermore, Lahmann et al, [26] who used data from 73.542 premenopausal and 103.344 postmenopausal women from 9 European countries taking part in the EPIC (European Prospective Investigation into Cancer and Nutrition) study, concluded that in postmenopausal women not taking exogenous hormones, weight, BMI and hip circumference were positively associated with breast cancer risk.…”

Section: Discussionmentioning

confidence: 91%

Cardiometabolic Factors and Breast Cancer: A Case-Control Study in Women

Mourouti¹,

Papavagelis²,

Kontogianni³

et al. 2013

TOHYPERJ

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Abstract:Background: Previous studies have suggested that individual cardiometabolic factors may be associated with an increased risk of breast cancer. Objective: To evaluate the association between individual cardiometabolic factors with breast cancer development. Design: A case -control study. Two-hundred-and-fifty consecutive, newly diagnosed breast cancer female patients (56±12 years) and 250, one-to-one age-matched with the patients, healthy volunteers (controls), were studied. A standardized, validated questionnaire assessing various socio-demographic, clinical, lifestyle and dietary characteristics, was applied through face-to-face interviews. Adherence to the Mediterranean diet was evaluated using the 11-components MedDietScore (theoretical range 0-55). A detailed medical history regarding the common co-morbidities (i.e., diabetes, hypertension, hypercholesterolemia) and their treatment was also recorded, while women were also categorized using the Body Mass Index (BMI) as an indicator of obesity. Results: Obesity (i.e., BMI>30 kg/m 2 ) was positively associated with the likelihood of having breast cancer. Conclusions: With the exception of obesity, none of the other tested cardiometabolic risk factors seemed to be a predisposing factor for breast cancer development.

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Section: Discussionmentioning

confidence: 91%

Cardiometabolic Factors and Breast Cancer: A Case-Control Study in Women

Mourouti¹,

Papavagelis²,

Kontogianni³

et al. 2013

TOHYPERJ

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“…The available data have shown a contrast: Heavier women have been found to be at increased risk of postmenopausal BC in most studies, whereas BMI is inversely associated with the risk of cancer among premenopausal (3)(4)(5) women. Recently, high weight and body fat in elder women were reported as an independent risk factor (6). Also, fat-free mass has been found positively associated with the risk of BC in postmenopausal women (7).…”

Section: Introductionmentioning

confidence: 98%

A Case-Control Study on Fat-to-Muscle Ratio and Risk of Breast Cancer

Ronco

Boeing

Stéfani

et al. 2009

Nutrition and Cancer

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Our objective was to analyze detailed anthropometric characterization for risk of breast cancer in Uruguayan women. The design was a case-control study. The setting was Pereira Rossell Women's Hospital, Montevideo, Uruguay. Subjects were 343 incident breast cancer cases and 1,042 frequency-matched healthy controls who were interviewed on menstrual and reproductive story; and a series of skin folds, circumferences, and diameters were measured to calculate fat and muscle fractions and the derived fat-to-muscle ratio (FMR). Odds ratio (ORs) coefficients were taken as estimates of relative risk derived from unconditional logistic regression. Muscle fraction was negatively associated with risk [OR for highest quartile = 0.23, 95% confidence interval (CI) = 0.15-0.34], fat fraction was positively associated (OR = 3.90, 95% CI = 2.62-5.80), and FMR was positively associated (OR = 4.45, 95% CI = 2.99-6.62). Stratified analyses by body mass index levels also showed risk increases for the highest tertiles of FMR, always displaying significant linear trends. Since increases of risk were found in overweight and in normal weight women, results suggest that fractions and amount of muscle and fat components might be risk factors for breast cancer on the basis of currently existing metabolic and immune interrelationships between adipose and muscular tissue given by glutamine, exercise-derived myokines, and other cytokines produced by these tissues.

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“…A positive association of central adiposity with postmenopausal BC risk and also a weaker association for premenopausal women were found in most of these studies. Absence of association with anthropometric measures in premenopausal women was described in certain populations, like the Chinese 8,9 . More recently, waist-to-hip ratio was associated with an increased risk in pre-menopausal Nigerian 10 and Asian-American women 11 and also the fat-free mass has been found to be positively associated with the risk of BC in postmenopausal women 12 .…”

Section: Introductionmentioning

confidence: 99%

“…Some studies examined regional adiposity and BC risk [4][5][6][7][8][9][10][11] . A positive association of central adiposity with postmenopausal BC risk and also a weaker association for premenopausal women were found in most of these studies.…”

Section: Introductionmentioning

confidence: 99%

Somatotype and risk of breast cancer: a case-control study in Uruguay

Ronco¹,

Mendoza

Varas³

et al. 2008

Rev. bras. epidemiol.

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According to the evidence, there is a need for more thorough assessment and quantification of body size and shape and the risk of breast cancer. Using the somatotype methodology, we carried out an original research in order to explore possible associations between body shape and the risk of breast cancer in Uruguayan women. With this objective, 254 recent breast cancer cases and 1,000 frequency-matched healthy controls were interviewed on menstrual and reproductive story, and a series of skinfolds, circumferences and diameters were measured specifically to calculate somatotype. A positive association with breast cancer was found for high endomorphy (Odds Ratio [OR] = 2.82, p < 0.001), mainly among premenopausal women (OR = 4.98, p <0.001) and normoweight women (OR = 5.12, p = 0.002), whereas almost no differences were observed for mesomorphic and ectomorphic women. Analysis showed a high mesoendomorphic pattern in the study population. Further studies are needed to confirm the present results obtained in a country with high incidence of the disease.

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Measures of Adiposity and Risk of Breast Cancer in Older Postmenopausal Women

Abstract: Higher adiposity is an independent risk factor for breast cancer in elderly women.

Cited by 45 publications

References 48 publications

Cardiometabolic Factors and Breast Cancer: A Case-Control Study in Women

Cardiometabolic Factors and Breast Cancer: A Case-Control Study in Women

A Case-Control Study on Fat-to-Muscle Ratio and Risk of Breast Cancer

Somatotype and risk of breast cancer: a case-control study in Uruguay

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