Fertilizer misapplications have induced widespread environmental deteriorations, climatic catastrophes, and economic losses; meanwhile, the Precision Agriculture (PA) endorsements have been influential in alleviating these issues. This study intended to tackle the fertilizer consumption inefficiencies by utilizing non-destructive remote sensing technologies, soil macronutrient distribution analysis, and a deep learning model. Specifically, an Unmanned Air Vehicle (UAV) was used in a cornfield to capture the plant's reflectance information for retrieving the Normalized Difference Vegetation Index (NDVI) during the vegetative and reproductive growth stages. Consequently, the field's soil samples were examined for their Nitrogen, Phosphorus, Potassium, and Carbon (NPKC) macronutrient constituencies. Finally, a Convolutional Neural Network-Regression model was developed to predict infield NPKC spatiotemporal variations in soil using the NDVI measurements. The deep learning model effectively determined the surpluses or shortages of the NPKC macronutrients within the cornfield throughout the growth stages. The model performed vigorously with R 2 values of 0.93, 0.92, 0.98, and 0.83 in predicting N, P, K, and C levels in soil, respectively. INDEX TERMS Convolutional Neural Network-Regression, Macronutrients in soil, NDVI, UAV Mr. Mustafa Jaihuni received a BSc degree in Electrical & Electronics Engineering in 2009 from Boğaziçi University, Istanbul, Turkey, and an M.S. degree in 2020 in Biosystems Engineering from Gyeongsang National University (GNU), Gyeongsangnam-do, Republic of Korea. Currently, he is a research student at GNU in the Smart Farm Systems Lab, department of Biosystems Engineering. He has published 2 articles in different Journals related to Agriculture, Renewable Energy and Smart Farming applications. Mr. Jaihuni's research interests are Remote Sensing, Deep Learning, ICT applications in Agriculture and Wind-Solar Renewable Energy Systems. Mr. Fawad Khan was born in Peshawar, Pakistan, in 1991. He received a BS (Hons) degree in Environmental Sciences and a Master's degree in Biosystems Engineering from the University of Peshawar (Pakistan) and Gyeongsang National University (Republic of Korea), respectively. He published seventeen articles in different Journals related to Agriculture and Horticulture, Energy, and Bio-systems engineering. Mr. Khan's research interests nutrients management, crop yield, and greenhouse gases