Measures of Psychopathology in Children With Complex Partial Seizures and Primary Generalized Epilepsy With Absence

Ott, Derek V. M.; Caplan, Rochelle; Guthrie, Donald; Siddarth, Prahba; Komo, Scott; Shields, W. Donald; Sankar, Raman; Kornblum, Harley I.; Chayasirisobhon, Sirichai

doi:10.1097/00004583-200108000-00012

Cited by 122 publications

(105 citation statements)

References 45 publications

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“…Piazzini et al [10] reported a greater prevalence of depression and anxiety in those with partial epilepsy than those with generalized epilepsy (temporal lobe epilepsy > frontal lobe epilepsy > idiopathic generalized epilepsy > controls). On the other hand, Ott et al [11] found that children with complex partial seizures, including TLE and idiopathic generalized epilepsy of the absence type have had similar rates of depression. TLE and depression appear to share several mechanisms, including impairments in serotonergic, noradrenergic, glutamatergic and GABAergic transmission [12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Kindling epileptogenesis in immature rats leads to persistent depressive behavior

Mazarati¹,

Shin²,

Auvin³

et al. 2007

Epilepsy & Behavior

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Depression is a frequent comorbidity in epilepsy patients. A variety of biological factors may underlie epilepsy-associated depression. We examined whether kindling-induced chronic increase in seizure susceptibility is accompanied by behavioral symptoms of depression. Three week-old Wistar rats underwent rapid kindling -84 initially subconvulsant electrical stimulations of ventral hippocampus delivered every five minutes -followed by depression-specific behavioral tests performed two and four weeks later. Kindled animals exhibited sustained increase in the immobility time in the forced swim test and the loss of taste preference towards calorie-free saccharin, as compared to controls. Initial loss of preference towards the intake of calorie-containing sucrose was followed by the increased consumption at four weeks. At both time points, animals exhibited enhanced seizure susceptibility upon test stimulations of the hippocampus. We conclude that neuronal plastic changes associated with kindling state are accompanied by the development of depressive behavior.

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Section: Introductionmentioning

confidence: 99%

Kindling epileptogenesis in immature rats leads to persistent depressive behavior

Mazarati¹,

Shin²,

Auvin³

et al. 2007

Epilepsy & Behavior

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“…There are high rates of comorbid MDD and anxiety disorders in adults (28)(29)(30)(31)(32)(33) and children with epilepsy (34)(35)(36)(37)(38)(39)(40)(41). Amygdala volume findings, however, vary with two studies showing increased volumes in presurgical TLE adults with depression (42,43) and two studies showing no change in volumes in individuals with TLE (44,45).…”

Section: Introductionmentioning

confidence: 99%

Amygdala volume and psychopathology in childhood complex partial seizures

Daley

Siddarth

Levitt

et al. 2008

Epilepsy & Behavior

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Purpose-This study compared amygdala volume in children with cryptogenic epilepsy, who had complex partial seizures (CPS), with age and gender matched normal children. It also examined the relationship of amygdala volumes with seizure variables and the presence of psychopathology in the patients.Methods-28 children with cryptogenic epilepsy, all of whom had CPS, and gender matched normal children, aged 6-16 years had magnetic resonance imaging (MRI) at 1.5 Tesla. Tissue was segmented and total brain volume and amygdala volumes obtained from manual tracings were computed.Results-There were no significant differences in the amygdala volume of the CPS and normal groups. Within the CPS group, the children with an affective/anxiety disorder had significantly larger left amygdala volumes compared to those with no psychopathology as well as greater amygdala asymmetry. Exploring the association of seizure variables to amygdala volumes yielded no significant predictors.Conclusions-In pediatric CPS left amygdala involvement might reflect effects of the neuropathology underlying comorbid affective or anxiety disorders on amygdala development rather than effects of on-going seizures.

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“…Epidemiological studies over the past 30 years have shown that behavioral disturbances are up to 4.8 times higher in children with epilepsy than in general population children (Davies et al, 2003, Austin & Caplan, 2007. It is nowwell accepted that as a group children with epilepsy have high rates of behavioral disturbance (Rodenburg et al, 2005) and psychiatric diagnoses (Ott et al, 2001;Caplan et al, 2004). In general, children with epilepsy display more attention problems and internalizing problems (withdrawal, somatic complaints, anxiety, and depression symptoms) than they do externalizing problems such as acting out and conduct problems (Ott et al, 2001;Caplan et al, 2004) A recent meta-analysis of findings from 46 studies contrasted behavior problems in children with epilepsy to control groups, siblings, and children with other chronic childhood conditions (Rodenburg et al, 2005).…”

Section: Psychological Effects Of Epilepsy On Childrenmentioning

confidence: 99%