The COVID-19 pandemic has fundamentally altered teaching and learning practices in higher education, with academic, social, and psychological consequences for students. The pivot to online and blended-learning models across has the potential to impact belongingness and social adjustment in students across identity groups – including students who identify as LGBTQ+, who have previously been shown to have lower perceptions of belongingness and social adjustment in the university context (Sotardi et al., 2021). This partial replication applied a mixed-methods, intersectional lens to investigate student belonging amongst LGBTQ+ and neurodivergent students.We found that belonging and social adjustment were predictors of academic self-efficacy for all students, but particularly LGBTQ+ students, during blended learning. Neurodivergent students demonstrated significantly lower wellbeing and academic self-efficacy than their neurotypical peers. All students we surveyed acknowledged that blended learning was associated with both benefits and challenges in the academic social spheres. These included increased flexibility and accessibility, but also difficulties with engagement, motivation, and socialising. However, the discourse among LGBTQ+ and neurodivergent students differed in that it explicitly referenced negative impacts to mental wellbeing, as well as the distortion of the university experience and student identity. They also referred to the importance of identity-based peer relationships in supporting their wellbeing.Our results suggest that future research should focus on the intersection of LGBTQ+ and neurodivergent students, as well as how universities can implement a hybrid model that offers the benefits of a blended-learning model without detracting from student engagement, motivation, and social opportunities for LGBTQ+ and neurodivergent students.