Objectives: to investigate evidence on effective strategies to reduce vaccine hesitancy in the general population in the context of the COVID-19 pandemic. Methods: scoping review, carried out by consulting the MEDLINE databases (access via PubMed), Cochrane Library, Web of Science, Scopus and the Virtual Health Library portal, according to the method proposed by the Joanna Briggs Institute. Original productions, published between 2020 and 2023, were included. Results: this review consisted of twelve (12) studies, with a predominance of randomized controlled clinical trials (91.7%). Regarding the level of evidence, the majority of investigations classified as level II (91.7%) and regarding the quality of the evidence/strength of recommendation of the studies, most were classified as high level (66.7%). Final Considerations: strategies to promote health education and literacy, motivation and community awareness regarding vaccination, with greater technological input, proved to be effective for reduce vaccine hesitancy in the population.