Measuring Composition of CD95 Death-Inducing Signaling Complex and Processing of Procaspase-8 in this Complex

Hillert-Richter, Laura K.; Lavrik, Inna N.

doi:10.3791/62842-v

Cited by 2 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Subsequently, the death-inducing signalling complex (DISC), a ligand-receptor-adaptor protein complex, is formed by a sequential process. The death ligand of DISC binds to DR to recruit an adaptor protein in order ( 98 , 99 ). The DISC activates caspase-8, which initiates apoptosis through cleavage of the downstream caspases ( 97 ).…”

Section: The Mechanism Of Apoptosis In Glaucomamentioning

confidence: 99%

Apoptosis in glaucoma: A new direction for the treatment of glaucoma (Review)

Xia,

Zhang

2024

Mol Med Rep

View full text Add to dashboard Cite

Glaucoma is a group of progressive optic nerve disorders characterized by the loss of retinal ganglion cells, a thinner retinal nerve fibre layer and cupping of the optic disk. Apoptosis is a physiological cell death process regulated by genes and plays a crucial role in maintaining tissue homeostasis, ensuring the natural development and immune defence of organisms. Apoptosis has been associated with glaucoma and inhibiting apoptosis by activating phosphatidylinositol 3-kinase-protein kinase B or other medicines can rescue pathological changes in glaucoma. Due to the complex crosstalk of apoptosis pathways, the pathophysiological mechanism of apoptosis in glaucoma needs to be fully elucidated. The present review aimed to discuss the mechanism of cell apoptosis in glaucoma, improve the understanding of the pathophysiology of glaucoma, summarize new directions for the treatment of glaucoma and lay the foundation for new treatment strategies for glaucoma.

show abstract

Section: The Mechanism Of Apoptosis In Glaucomamentioning

confidence: 99%