The markets in which organizations currently operate require them to use behaviour based on both exploitation strategy and exploration strategy, each of which contributes fundamental benefits for the firm's success. Exploitation strategy attempts to obtain the maximum advantage from existing abilities, whereas exploration strategy searches for new ways for the organization to adapt. Further, since manufacturing markets are characterized by short product life, they require a high level of manufacturing flexibility, which can play a crucial role in the development of the exploitation and exploration strategies. This study analyses the relationship of manufacturing flexibility to exploitation and exploration strategies, taking into account an issue of maximum international scope: the implementation of ISO standards. In many international markets, ISO implementation is crucial in enabling organizations to be competitive. However, no consensus has been reached concerning the real benefits that these systems provide to the organizations that implement them. The main goal of our study is to analyse whether there are significant differences in the relationship of manufacturing flexibility to exploitation and exploration strategies in ISO 9001:2000 certified organizations and non-certified organizations. Our results show that most of the relationships analysed are only significant in ISO certified organizations. As an added value, the study analyses the relationship of exploitation and exploration strategies to organizational learning orientation and finds this relationship to be significant in all cases.