Measuring Epstein–Barr virus (EBV) load: the significance and application for each EBV‐associated disease

Kimura, Hiroshi; Ito, Yoshinori; Suzuki, Ritsuro; Nishiyama, Yukihiro

doi:10.1002/rmv.582

Cited by 138 publications

(158 citation statements)

References 109 publications

(135 reference statements)

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“…During infectious mononucleosis, EBV virions and naked EBV DNA pass into the peripheral blood and can be detected in serum or plasma samples within 14 days after the onset of symptoms (De Paschale and Clerici, 2012;Kimura et al, 2008). However, EBV DNA can also be detected from reactivated EBV infections (Dohno et al, 2010) and little is known about the EBV DNA prevalence rate in asymptomatic infections.…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence of Anti-EBV IgG among Various Age Groups from Khon Kaen Province, Thailand

Suntornlohanakul¹,

Wanlapakorn²,

Vongpunsawad³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Epstein-Barr virus (EBV) is an extremely common herpesvirus that may cause asymptomatic infection or various diseases, including infectious mononucleosis, certain lymphoproliferative diseases and several types of neoplasms. Vaccine development is an important strategy to reduce the burden of EBV-associated diseases and the timing of vaccinations should be before primary infection occurs. In the past, more than 90% of Thai children were infected with EBV in early childhood. Now, due to the improved healthcare system in Thailand, we aim to determine current prevalence of EBV infection among people in different age groups. A total of 538 sera were collected from residents of Khon Kaen province in northeastern Thailand for detecting anti-EBV IgG. Sera of infants under 2-years-old were also tested for anti-EBV IgM and EBV-DNA. The prevalence of anti-EBV IgG was 47.1% (95% CI: 23.3-70.8) in infants aged 0-6 months, 34.9% (95% CI: 23.1-46.7) in those aged 6-24 months, 87.9% (95% CI: 79.5-96.3) in children aged 3-5 years and then maintained at above 95% through adulthood. These seropositivity rates among Thai children remain similar to those found in a previous study conducted 20 years ago. Thai children are still exposed to EBV from an early age. Therefore, a prophylactic vaccine should be given within the first two years of life.

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Section: Discussionmentioning

confidence: 99%

Seroprevalence of Anti-EBV IgG among Various Age Groups from Khon Kaen Province, Thailand

Suntornlohanakul¹,

Wanlapakorn²,

Vongpunsawad³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…Primary EBV infection is usually asymptomatic, and the EBV then establishes latent infection in memory B cells, which do not permit viral replication [29]. Although newly infected naive B cells have the phenotypes of transformed cells, they are controlled by both EBV-specific cytotoxic T lymphocytes (CTL) and natural killer (NK) cells unless immunity is suppressed [29,30].…”

Section: Resultsmentioning

confidence: 99%

A Case of Age-Related Epstein–Barr Virus (EBV)-Associated B Cell Lymphoproliferative Disorder, so-called Polymorphous Subtype, of the Mandible, with a Review of the Literature

Kikuchi

Fukunaga²,

Inoue

et al. 2012

Head and Neck Pathol

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Epstein-Barr virus (EBV) is known to be associated with the development of lymphomas in immunocompromised patients. Recently, age-related immune impairment has been recognized as a predisposing factor in the development of EBV-driven lymphoproliferative disorders (LPDs) in elderly patients without any known immunodeficiency or prior lymphoma. In approximately 70 % of reported cases, the affected sites have been extranodal, such as the skin, lung, tonsil and stomach. However, age-related EBV-associated B cell (EBV ? B cell) LPD is extremely rare in the oral cavity. Here we report a 71-year-old Japanese man who developed an EBV ? B cell LPD resembling classical Hodgkin lymphoma (CHL)-so-called polymorphous subtype-of the mandible. Histopathologically, infiltration of large atypical lymphoid cells including Hodgkin or Reed-Sternberg-like cells into granulation tissue with marked necrosis was found in the mandibular bone. Immunohistochemical analysis revealed that the large atypical Hodgkin or ReedSternberg-like cells were CD3-, CD15-, CD20?, CD30? and Epstein-Barr virus (EBV)-latent infection membrane protein-1 (LMP-1)?. In situ hybridization (ISH) demonstrated EBV-encoded small RNA (EBER) ? in numerous Hodgkin or Reed-Sternberg-like cells. EBNA-2 was detected by polymerase chain reaction (PCR) using an extract from the formalin-fixed, paraffin-embedded specimen. To our knowledge, this is the first reported case of the polymorphous subtype of age-related EBV ? B cell LPD affecting the mandible.

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“…15,16,18 Quantitative PCR for EBV DNA can be used to decide on the treatment because the detection of EBV-DNA by PCR is an important prognostic factor. 19 On the basis of the smear findings from bone marrow aspiration and high level of EBV-DNA in PBLs in our case, we assessed the presence of EBV-HLH after the first CHOPE therapy. HSCT therapy was successful and the patient has been in remission for 2 years.…”

Section: Discussionmentioning

confidence: 99%

Unrelated Bone Marrow Transplantation Induced Long-Term Remission in a Patient with Life-Threatening Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis

Kunitomi

Kimura

Ito

et al. 2011

J Clin Exp Hematopathol

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We present a case of life-threatening Epstein-Barr virus (EBV)-associated hemophagocytic lymphohistiocytosis (HLH) with severe hepatitis that was successfully treated by allogeneic stem cell transplantation from an unrelated donor. A 26-year-old woman was admitted to hospital with a high fever and liver dysfunction. Laboratory tests, including bone marrow aspiration, revealed severe HLH that occurred after EBV infection. High-dose methylprednisolone and etoposide therapy did not control the disease. We could control the HLH, but the EBV viremia continued following the CHOPE (cyclophosphamide, doxorubicin, vincristine, prednisone, and etoposide) chemotherapy regimen. Therefore, the patient underwent allogeneic bone marrow transplantation from an HLA-matched, unrelated donor. The patient has remained in good condition without disease recurrence for 2 years after bone marrow transplantation. Although there is no consensus regarding allogeneic stem cell transplantation for EBV-HLH, it is the treatment of choice for aggressive EBV-HLH when the patient is refractory to intensive chemotherapy. 〔J Clin Exp Hematopathol 51(1) : 57-61, 2011〕

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Measuring Epstein–Barr virus (EBV) load: the significance and application for each EBV‐associated disease

Cited by 138 publications

References 109 publications

Seroprevalence of Anti-EBV IgG among Various Age Groups from Khon Kaen Province, Thailand

Seroprevalence of Anti-EBV IgG among Various Age Groups from Khon Kaen Province, Thailand

A Case of Age-Related Epstein–Barr Virus (EBV)-Associated B Cell Lymphoproliferative Disorder, so-called Polymorphous Subtype, of the Mandible, with a Review of the Literature

Unrelated Bone Marrow Transplantation Induced Long-Term Remission in a Patient with Life-Threatening Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis

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