Measuring estradiol levels after human chorionic gonadotropin administration for in vitro fertilization is not clinically useful

A decrease in serum estradiol levels after human chorionic gonadotrophin administration predicts significantly lower clinical pregnancy and live birth rates in in vitro fertilization cycles

“…Patients were stratified into three groups based on E2 response to hCG administration: .10% increase in post-hCG E2 levels (Group A), plateau (+10% change) in post-hCG E2 levels (Group B) and .10% decrease in post-hCG E2 levels (Group C). These classifications are consistent with previous studies (Meyer et al, 1999;Chiasson et al, 2007). Analysis of variance and the Kruskal -Wallis test were performed to compare the three groups.…”

“…In fact, the serum E2 concentration alone on the day of hCG has been reported to be a poor predictor of IVF outcome (Kyrou et al, 2009). A few studies have assessed the significance of change in E2 levels on the day following hCG administration on IVF cycle outcome with conflicting results (Laufer et al, 1986;Meyer et al, 1999;Chiasson et al, 2007). All these studies are hampered by small sample size and only one study examines the key IVF outcome of live birth rates (Chiasson et al, 2007).…”

“…A few studies have assessed the significance of change in E2 levels on the day following hCG administration on IVF cycle outcome with conflicting results (Laufer et al, 1986;Meyer et al, 1999;Chiasson et al, 2007). All these studies are hampered by small sample size and only one study examines the key IVF outcome of live birth rates (Chiasson et al, 2007). In an effort to address these limitations, our study was designed to evaluate the relationship between change in E2 levels in response to hCG administration and IVF outcomes including clinical pregnancy and live births.…”

Serum progesterone on the day of human chorionic gonadotropin administration predicts clinical pregnancy of sibling frozen embryos

“…While many centers frequently measure serum levels of sex steroids during COH, the data on predictive value of hormonal parameters on the likelihood of pregnancy are limited. E2 levels are routinely measured during COH, yet they appear to be of little utility in predicting pregnancy (18). Serum P levels during COH have attracted attention as a possible predictor of pregnancy.…”

Brain derived neurotrophic factor circulating levels in patients undergoing IVF

“…It was believed that estradiol levels represented undoubtedly the best marker for the quality and maturity of oocytes [1]. However, recent studies have clearly demonstrated that levels of estradiol following hCG administration, whether increasing, unchanged or decreasing, are not in any way correlated with achievement of pregnancy [2,3]. Moreover, it is ever so evident the ovarian follicular development and oocyte maturation are regulated by a complex steroid hormone-growth factor interactions.…”