Measuring health-related quality of life in patients with conservatively managed stage 5 chronic kidney disease: limitations of the Medical Outcomes Study Short Form 36: SF-36

Erez, Gilli; Selman, Lucy E; Murtagh, Fliss E.M.

doi:10.1007/s11136-016-1313-7

Cited by 46 publications

(43 citation statements)

References 75 publications

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“…The proportion of patients experiencing a change exceeding the minimal clinically important difference (MCID) threshold was determined for each SF‐36 subscale at 12 months posttransplant. The threshold values reflect the minimum score change that is clinically meaningful for patients and were obtained from a study of patients with stage 5 chronic kidney disease …”

Section: Methodsmentioning

confidence: 99%

Trajectories of health-related quality of life among renal transplant patients associated with graft failure and symptom distress: Analysis of the BENEFIT and BENEFIT-EXT trials

Purnajo

Beaumont

Polinsky

et al. 2020

American Journal of Transplantation

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Understanding the correlation between transplant symptoms, health‐related quality of life (HRQoL), and graft outcomes is needed to support patient‐focused drug development and posttransplant management. A post‐hoc analysis of patient‐reported outcomes from the Phase III belatacept trials was conducted in order to investigate the interrelationship between trajectories of HRQoL, symptom experience, and allograft outcomes. HRQoL and symptom experience were evaluated using Short‐Form 36 Survey (SF‐36) and Modified Transplant Symptom Occurrence and Distress Scale (MTSOSD‐59R), respectively. HRQoL was captured in 831 eligible renal transplant patients at baseline, 12, 24, and 36 months posttransplant. Following transplantation, patients reported improvements in all SF‐36 subscales compared to baseline. Latent class analysis revealed four trajectories in perceived general health, which were associated with graft failure after adjustment. Compared to patients with good perceived health, patients with fair and poor perceived health had 4.7 (95% confidence interval [CI] 1.5‐14.8, P < .01) and 19.8 (95% CI 5.9‐66.0, P < .01) times the risk of graft failure, respectively. Using multinomial logistic regression, different sets of symptoms were associated with perceived general health at baseline and 12 months posttransplant. The study supports monitoring HRQoL and symptom experience to capture each patient's health perspective, improve drug development, and optimize posttransplant management.

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Section: Methodsmentioning

confidence: 99%

Trajectories of health-related quality of life among renal transplant patients associated with graft failure and symptom distress: Analysis of the BENEFIT and BENEFIT-EXT trials

Purnajo

Beaumont

Polinsky

et al. 2020

American Journal of Transplantation

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“…Chronic-kidney-disease-specific instruments are PROMs that are tailored to the specific symptom burden and disease experience by patients with CKD (see Table 2 ) ( 22 , 116 , 127 , 159 ). These instruments are often very specific, thus avoiding the ceiling or floor effects observed when using generic instruments ( 127 , 132 ). The specificity of the questions, however, usually precludes its use in other populations thus limiting generalizability of results ( 127 , 133 ).…”

Section: Patient-reported Outcome Measuresmentioning

confidence: 99%

Patient-Reported Outcomes in Patients with Chronic Kidney Disease and Kidney Transplant—Part 1

et al. 2018

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Chronic kidney disease (CKD) is a complex medical condition that is associated with several comorbidities and requires comprehensive medical management. Given the chronic nature of the condition, its frequent association with psychosocial distress, and its very significant symptom burden, the subjective patient experience is key toward understanding the true impact of CKD on the patients’ life. Patient-reported outcome measures are important tools that can be used to support patient-centered care and patient engagement during the complex management of patients with CKD. The routine collection and use of patient-reported outcomes (PROs) in clinical practice may improve quality of care and outcomes, and may provide useful data to understand the disease from both an individual and a population perspective. Many tools used to measure PROs focus on assessing health-related quality of life, which is significantly impaired among patients with CKD. Health-related quality of life, in addition to being an important outcome itself, is associated with clinical outcomes such as health care use and mortality. In Part 1 of this review, we provide an overview of PROs and implications of their use in the context of CKD. In Part 2, we will review the selection of appropriate measures and the relevant domains of interest for patients with CKD.

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“…Many studies fail to mention the existence of missing and the methods of handing it [2,3]. Others merely alluded to the default method or typically discard of samples with missing value to obtain a complete dataset [4]. These methods, known as listwise deletion or complete case analysis, reduce even more sample size available for analysis [5].…”

Section: Introductionmentioning

confidence: 99%

The ability of different imputation methods for missing values in mental measurement questionnaires

Xia

Zhang

et al. 2020

BMC Med Res Methodol

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Background: Incomplete data are of particular important influence in mental measurement questionnaires. Most experts, however, mostly focus on clinical trials and cohort studies and generally pay less attention to this deficiency. We aim is to compare the accuracy of four common methods for handling items missing from different psychology questionnaires according to the items non-response rates. Method: All data were drawn from the previous studies including the self-acceptance scale (SAQ), the activities of daily living scale (ADL) and self-esteem scale (RSES). SAQ and ADL dataset, simulation group, were used to compare and assess the ability of four imputation methods which are direct deletion, mode imputation, Hot-deck (HD) imputation and multiple imputation (MI) by absolute deviation, the root mean square error and average relative error in missing proportions of 5, 10, 15 and 20%. RSES dataset, validation group, was used to test the application of imputation methods. All analyses were finished by SAS 9.4. Results: The biases obtained by MI are the smallest under various missing proportions. HD imputation approach performed the lowest absolute deviation of standard deviation values. But they got the similar results and the performances of them are obviously better than direct deletion and mode imputation. In a real world situation, the respondents' average score in complete data set was 28.22 ± 4.63, which are not much different from imputed datasets. The direction of the influence of the five factors on self-esteem was consistent, although there were some differences in the size and range of OR values in logistic regression model. Conclusion: MI shows the best performance while it demands slightly more data analytic capacity and skills of programming. And HD could be considered to impute missing values in psychological investigation when MI cannot be performed due to limited circumstances.

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Measuring health-related quality of life in patients with conservatively managed stage 5 chronic kidney disease: limitations of the Medical Outcomes Study Short Form 36: SF-36

Cited by 46 publications

References 75 publications

Trajectories of health-related quality of life among renal transplant patients associated with graft failure and symptom distress: Analysis of the BENEFIT and BENEFIT-EXT trials

Trajectories of health-related quality of life among renal transplant patients associated with graft failure and symptom distress: Analysis of the BENEFIT and BENEFIT-EXT trials

Patient-Reported Outcomes in Patients with Chronic Kidney Disease and Kidney Transplant—Part 1

The ability of different imputation methods for missing values in mental measurement questionnaires

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