Measuring health-related quality of life in colorectal cancer patients: systematic review of measurement properties of the EORTC QLQ-CR29

Hout, Anja van der; Neijenhuijs, Koen Ilja; Jansen, Femke; Uden–Kraan, Cornelia F. van; Aaronson, Neil K.; Grøenvold, Mogens; Holzner, Bernhard; Terwee, Caroline B.; Poll‐Franse, Lonneke V. van de; Cuijpers, Pim; Leeuw, Irma M. Verdonck‐de

doi:10.1007/s00520-019-04764-7

Cited by 21 publications

(17 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Second, while discussion on the methodology used was limited given the small number of studies available, we noted the lack of quantitative scales specifically validated for CRC patients. Only one scale used the EORTC QLQ‐CR29 36 which measures QOL domains characteristic to CRC. The inclusion of cancer‐specific scales is essential in uncovering psychosocial experiences unique to CRC, such as the influence of stoma, sexual dysfunction, and embarrassment with bowel movements.…”

Section: Discussionmentioning

confidence: 99%

Understanding the psychosocial impact of colorectal cancer on young‐onset patients: A scoping review

et al. 2022

View full text Add to dashboard Cite

Objective:The incidence of young-onset (<50 years) colorectal cancer (CRC) has been increasing internationally. The psychosocial experience of younger cancer patients is vastly different from older patients, especially in domains such as financial toxicity, body image, and sexual dysfunction. What is unknown is the cancer type-specific experience. The aim of the current scoping review was to examine (1) the psychosocial factors and/or outcomes associated with young-onset CRC and (2) other determinants that influences these outcomes. Methods:A systematic search was conducted on four databases (PubMed, CINAHL, Scopus and PsycINFO) from inception to December 2020 using key terms and combinations. Primary literature that examined the psychosocial (e.g., quality-of-life, emotional, social, sexual) impact of young-onset CRC were included.Results: A total of 1389 records were assessed by four reviewers, with a total of seven studies meeting inclusion criteria (n = 5 quantitative, n = 1 qualitative and n = 1 case series). All studies indicated there was significant psychosocial impact in younger CRC patients, including emotional impact, social impact, physical burden, sexual impact, work impact, unmet needs, financial impact and global quality of life. Three studies explored other determinants that influenced the psychosocial experience and found that socioeconomic background (e.g., being female, lower education), CRC treatment (e.g., chemotherapy) and health status were associated with worse psychosocial impact.Conclusions: Young-onset CRC patients face severe psychosocial impact unique to this age group, such as self-image and sexual impact. Social support services and resources needs to be uniquely tailored. More empirical investigations are required to understand its long-term impact and influence of other psychosocial domains.

show abstract

Section: Discussionmentioning

confidence: 99%

Understanding the psychosocial impact of colorectal cancer on young‐onset patients: A scoping review

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Scores are transformed linearly, giving a score between zero and 100. The results of our study were compared to the results of other studies that showed that the higher the scores, the better they function on the functioning scales and a higher level of symptoms on the symptoms scale [27].…”

Section: Discussionmentioning

confidence: 85%

The Quality of Life of Patients with Hereditary Nonpolyposis Colorectal Cancer Undergoing Preoperative Chemoradiation

et al. 2020

View full text Add to dashboard Cite

Of all the neoplastic sites, colorectal cancer (CRC) is one of the most common cancers in the family. Studies estimate that approximately 30% of all the CRC cases are a hereditary form of the disease with a potentially high impact on the quality of life (QoL), with a high risk of recurrence, and with bio–psycho–social functioning. The aim of the study was to assess the QoL of colorectal cancer patients with genetic risk by using the European Organisation for Research and Treatment of Cancer (EORTC) questionnaire version QLQ-CR29. Materials and methods: The cross-sectional, single-center study was performed on a group of 32 patients with genetic risk of colorectal cancer, who underwent preoperative chemoradiation and surgery. Results: The series of values for the scores on the symptom scale varied between 15 and 30, and the average level of symptom scores did not differ significantly between gender (22.0 vs. 22.75; p = 0.636), highlighting a moderate impairment of QoL. Scores for the emotional functioning scale were significantly lower in men (10.33 vs. 13.25; p = 0.049), as were the scores for the physical functions (15.67 vs. 19.15; p = 0.039), showing a decrease in QoL. Conclusions: The overall score showed an average QoL in patients with colorectal cancer with genetic risk, highlighting significant differences in psycho-emotional functioning between women and men.

show abstract

“…For this second search, a sensitive PubMed search filter developed by Terwee et al [ 37 ] was applied. Translations of this filter for the remaining databases were taken from the COSMIN website and from other published COSMIN reviews [ 38 , 39 ] with permission from the authors. Both searches were conducted until March 2021 without restriction regarding the time of publication (databases were searched from inception).…”

Section: Methodsmentioning

confidence: 99%

Identification of tools used to assess the external validity of randomized controlled trials in reviews: a systematic review of measurement properties

Jung

Balzer

Braun

et al. 2022

BMC Med Res Methodol

View full text Add to dashboard Cite

Background Internal and external validity are the most relevant components when critically appraising randomized controlled trials (RCTs) for systematic reviews. However, there is no gold standard to assess external validity. This might be related to the heterogeneity of the terminology as well as to unclear evidence of the measurement properties of available tools. The aim of this review was to identify tools to assess the external validity of RCTs. It was further, to evaluate the quality of identified tools and to recommend the use of individual tools to assess the external validity of RCTs in future systematic reviews. Methods A two-phase systematic literature search was performed in four databases: PubMed, Scopus, PsycINFO via OVID, and CINAHL via EBSCO. First, tools to assess the external validity of RCTs were identified. Second, studies investigating the measurement properties of these tools were selected. The measurement properties of each included tool were appraised using an adapted version of the COnsensus based Standards for the selection of health Measurement INstruments (COSMIN) guidelines. Results 38 publications reporting on the development or validation of 28 included tools were included. For 61% (17/28) of the included tools, there was no evidence for measurement properties. For the remaining tools, reliability was the most frequently assessed property. Reliability was judged as “sufficient” for three tools (very low certainty of evidence). Content validity was rated as “sufficient” for one tool (moderate certainty of evidence). Conclusions Based on these results, no available tool can be fully recommended to assess the external validity of RCTs in systematic reviews. Several steps are required to overcome the identified difficulties to either adapt and validate available tools or to develop a better suitable tool. Trial registration Prospective registration at Open Science Framework (OSF): 10.17605/OSF.IO/PTG4D.

show abstract

Measuring health-related quality of life in colorectal cancer patients: systematic review of measurement properties of the EORTC QLQ-CR29

Cited by 21 publications

References 38 publications

Understanding the psychosocial impact of colorectal cancer on young‐onset patients: A scoping review

Understanding the psychosocial impact of colorectal cancer on young‐onset patients: A scoping review

The Quality of Life of Patients with Hereditary Nonpolyposis Colorectal Cancer Undergoing Preoperative Chemoradiation

Identification of tools used to assess the external validity of randomized controlled trials in reviews: a systematic review of measurement properties

Contact Info

Product

Resources

About