Welcome to the first Issue of Volume 5 of the Journal of Data Mining in Genomics and Proteomics (JDMGP). As in previous publications [1,2], articles compiled in the present issue of JDMGP are not centered on a sole topic. Instead, the Publisher, the Editorial Board and Reviewers have succeeded in assembling a compendium of nine articles that cover a wide range of bioinformatics applications ranging from bioinformatics strategies and challenges in proteome analysis to structural biology and the analysis coding or non-coding DNA expression under various conditions to map construction, ranking of genomes and strategies for sequence alignments.