Measuring longitudinal cognition: Individual tests versus composites

Jonaitis, Erin M.; Koscik, Rebecca L.; Clark, Lindsay R.; Ma, Yue; Betthauser, Tobey J.; Berman, Sara E.; Allison, Samantha L.; Mueller, Kimberly D.; Hermann, Bruce P.; Hulle, Carol A. Van; Christian, Bradley T.; Bendlin, Barbara B.; Blennow, Kaj; Zetterberg, Henrik; Carlsson, Cynthia M.; Asthana, Sanjay; Johnson, Sterling C.

doi:10.1016/j.dadm.2018.11.006

Cited by 94 publications

(114 citation statements)

References 49 publications

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“…Patients were then separated into two memory groups based on a mean composite delayed memory score (combined delayed story recall and delayed wordlist recall). 21,22 Patients with scores < 85 were classified as having "impaired" memory (n = 10), and those with mean standard scores of 85 or above were classified as having "intact" memory (n = 13).…”

Section: Memory Measures and Classificationmentioning

confidence: 99%

Verbal memory dysfunction is associated with alterations in brain transcriptome in dominant temporal lobe epilepsy

et al. 2020

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Objective: Memory dysfunction is prevalent in many neurological disorders and can have a significant negative impact on quality of life. The genetic contributions to memory impairment in epilepsy, particularly temporal lobe epilepsy (TLE), remain poorly understood. Here, we compare the brain transcriptome between TLE patients with and without verbal memory impairments to identify genes and signaling networks important for episodic memory. Methods: Brain tissues were resected from 23 adults who underwent dominant temporal lobectomy for treatment of pharmacoresistant epilepsy. To control for potential effects of APOE on memory, only those homozygous for the APOE ε3 allele were included. A battery of memory tests was performed, and patients were stratified into two groups based on preoperative memory performance. The groups were well matched on demographic and disease-related variables. Total RNA-Seq and small RNA-Seq were performed on RNA extracted from the brain tissues. Pathway and integrative analyses were subsequently performed. Results: We identified 1092 differentially expressed transcripts (DETs), with the majority (71%) being underexpressed in brain tissues from patients with impaired memory compared to those from patients with intact memory. Enrichment analysis revealed overrepresentation of genes in pathways pertaining to brain-related neurological dysfunction, including a subset associated with neurodegenerative diseases, memory, and cognition (APP, MAPT, PINK1). Despite including patients with identical APOE genotypes, we identify APOE as a differentially expressed gene associated with memory status. Small RNA-Seq identified four differentially expressed microRNAs (miRNAs) that were predicted to target a subset (22%) of all DETs. Integrative analysis showed that these miRNA-predicted DET targets impact brainrelated pathways and biological processes also pertinent to memory and cognition. Significance: TLE-associated memory status may be influenced by differences in gene expression profiles within the temporal lobe. Upstream processes influencing 2204 | BUSCH et al.

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Section: Memory Measures and Classificationmentioning

confidence: 99%

Verbal memory dysfunction is associated with alterations in brain transcriptome in dominant temporal lobe epilepsy

et al. 2020

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“…A limitation of the clinical progression analysis was its circularity: story recall total score is a factor used in determining cognitive impairment in the WRAP consensus process. In future analyses, we can use actuarial definitions of impairment (Bondi et al, 2014;Jak et al, 2016) based on tests not including Logical Memory and our internally derived norms (Clark, Koscik, et al, 2016;Koscik et al, 2019;Koscik et al, 2014) to compare how the lexical categories predict progression relative to the traditionally-used total scores.…”

Section: Discussionmentioning

confidence: 99%

“…Recently our group compared several versions of the PACC, as well as theoretically derived cognitive composite scores, and found that within the WRAP group a version referred to as "PACC-3" was sensitive to cognitive decline. This version omits the MMSE and includes an average of standardized scores from total recall from Rey AVLT, delayed recall from Logical Memory A & B, and Digit Symbol Substitution (Jonaitis et al, 2019). In secondary analyses, we examined whether the PACC-3 from the first available visit (median visit = 2) would predict morel variability in PiB positivity than the lexical categories variables.…”

Section: Secondary Predictor: the Preclinical Cognitive Composite Scomentioning

confidence: 99%

“…These sensitivity analyses sought to examine whether the results observed using continuous proper name and verb data persisted when simplified to categorical levels. In additional sensitivity analyses, we also examined whether the proper names model would explain more variability in PiB(+) status than the WRAP version (Jonaitis et al, 2019) of a commonly used cognitive composite score, the Preclinical Alzheimer's Cognitive Composite (PACC) (Donohue et al, 2014). The PACC-3 composite score from visit 2 was not associated with the most recent PiB status.…”

Section: The Relationship Between Lexical Categories and Beta-amyloidmentioning

confidence: 99%

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Proper names from story recall are associated with beta-amyloid in cognitively unimpaired adults at risk for Alzheimer's disease

Mueller

Koscik

et al. 2020

Preprint

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Proper names from story recall are associated with beta-amyloid in cognitively unimpaired adults at risk for Alzheimer's disease ABSTRACT Due to advances in the early detection of Alzheimer's disease (AD) biomarkers including betaamyloid (Ab), neuropsychological measures that are sensitive to concurrent, subtle changes in cognition are critically needed. Story recall tasks have shown sensitivity to early memory declines in persons with Mild Cognitive Impairment and early stage dementia, as well as in persons with autosomal dominantly inherited AD up to 10 years prior to a dementia diagnosis. However, the evidence is inconclusive regarding relationships between evidence of Ab and story recall measures. Because story recall tasks require the encoding and delayed retrieval of several lexical-semantic categories, such as proper names, verbs, and numerical expressions, and because lexical categories have been shown to be differentially impaired in persons with MCI, we focused on item-level analyses of lexical-semantic retrieval from a quintessential story recall task, Logical Memory from the Wechsler Memory Scale. Our objective was to investigate whether delayed recall of lexical categories (proper names, verbs and/or numerical expressions), as well as the traditional total score measure, was associated with "preclinical AD," or cognitively unimpaired adults with positive Ab deposition on positron emission tomography (PET) neuroimaging using Pittsburgh Compound B. We developed an item-level scoring system, in which we parsed items into lexical categories and examined the immediate and delayed recall of these lexical categories from 217 cognitively unimpaired participants from the Wisconsin Registry for Alzheimer's Prevention. We performed binary logistic regression models with story recall score as predictor and Ab status (positive/negative) as the outcome. Using baseline Logical Memory data, proper names from delayed story recall were significantly associated with Ab status, such that participants who recalled more proper names were less likely to be classified as PiB(+) (odds ratio = .58, p=.01). None of the other story recall variables, including total score, were associated with PiB status. Secondary analyses determined that immediate recall of proper names was not significantly associated with Ab, suggesting a retrieval deficit rather than that of encoding. The present findings suggest that lexical semantic retrieval measures from existing story recall tasks may be sensitive to Ab deposition, and may provide added utility to a widelyused, long-standing neuropsychological test for early detection of cognitive decline on the AD continuum.

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“…Global scores fail to indicate performance on specific cognitive abilities that may hold stronger relationships with sQOL. Using methods such as factor analysis to identify latent factors from among broader cognitive test batteries, such that multiple items load on each factor to create composite scores, can improve the reliability and efficiency of measurement [14]. Applying such an approach to examine the cognitive-sQOL relationship could be beneficial.…”

Section: The Cognition-sqol Relationshipmentioning

confidence: 99%

Impaired meaning-based cognitive skills are specifically associated with poorer subjective quality of life in schizophrenia

Tan

Rossell

Lee

2020

Personalized Medicine in Psychiatry

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Measuring longitudinal cognition: Individual tests versus composites

Cited by 94 publications

References 49 publications

Verbal memory dysfunction is associated with alterations in brain transcriptome in dominant temporal lobe epilepsy

Verbal memory dysfunction is associated with alterations in brain transcriptome in dominant temporal lobe epilepsy

Proper names from story recall are associated with beta-amyloid in cognitively unimpaired adults at risk for Alzheimer's disease

Impaired meaning-based cognitive skills are specifically associated with poorer subjective quality of life in schizophrenia

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