Measuring participation in individuals with Parkinson disease: relationships with disease severity, quality of life, and mobility

Abstract

Purpose: Our aims were to: 1) describe participation in people with Parkinson disease (PD), 2) evaluate the relationship between quality of life and participation, and 3) determine which mobility measures predict participation. Methods:Participants with idiopathic PD (n=62) were tested off medication for participation (Activity Card Sort), quality of life (PDQ-39), disease severity (MDS-UPDRS), and mobility (Berg Balance Scale, Five Time Sit to Stand (FTSTS) , Six Minute Walk, forward walking velocity, dual-task walking velocity, andFreezing of Gait Questionnaire (FOGQ)). Relationships of all variables to participation were examined using Pearson correlations. Subsequent regression analysis was employed to determine which mobility measures best predicted participation. Results:Participants with PD retained, on average, 78.3% (SD = 15.6%) of total activities. Participation was negatively correlated with all PDQ-39 domains (r range -.36 to .-78, all p < 0.005) with the mobility domain having the strongest correlation. All mobility measures were significantly correlated with participation, with the final regression model including only FTSTS and FOGQ which combined explained 37% of the variance in participation.Conclusions: Participation is highly related to mobility-related QOL and may be most impacted by ability to stand up from a chair and freezing of gait in those with PD.

Concordance between severity of disease, prevalence of nonmotor symptoms, patient-reported quality of life and disability and use of medication in Parkinson’s disease

“…Among motor symptoms, the most common and relevant determinants found are dyskinesias, motor fluctuations, axial impairment, lower extremity strength and freezing of gait [8][9][10][11][12]. Among nonmotor symptoms, depression, dementia, psychosis, cognitive impairment, apathy and sleep disorders (such as urinary incontinence, restlessness, morning fatigue and somnolence) were found to be the most common and relevant determinants of reduced HRQoL and increased disability [8,9,11,13,14].…”

Effects of augmented visual feedback during balance training in Parkinson's disease: A pilot randomized clinical trial

“…This is important as mobility-related quality of life is closely linked to social participation [2] while impaired postural control contributes significantly to falls [3]. Balance and gait-related symptoms tend to be largely resistant to pharmacological treatment [4].…”

Dance therapy for individuals with Parkinson&#39;s disease: improving quality of life

“…Participation, defined as involvement in a life situation, is especially related to mobility-related HRQOL and the ability to do functional tasks like rising from a chair. 55 Potentially, some individuals …”