ABSTRACT. Objective: Given the high prevalence of marijuana use among college students, it is imperative to determine the factors that may reduce risk of problematic marijuana use and/or the development of cannabis use disorder. We examined marijuana protective behavioral strategies (PBS) as a proximal predictor of marijuana-related outcomes and a mediator of the associations between other known risk/protective factors and marijuana-related outcomes. Method: Using data from a sample of 2,129 past-month marijuana users, collected from 11 universities in the United States, we examined marijuana PBS use as a mediator of the effects of sex, age at first use, impulsivity-like traits, and marijuana use motives on marijuana use frequency and marijuanarelated consequences. Results: Marijuana PBS was identified as a robust negative predictor of marijuana use frequency and marijuana-related consequences. Further, Marijuana PBS use fully or partially mediated the effects of sex, premeditation, perseverance, coping motives, enhancement motives, conformity motives, and expansion motives on marijuana outcomes. Conclusions: Our results suggest that marijuana PBS use is a good candidate to be considered as a mechanism by which marijuana users moderate their marijuana use and attenuate their risk of experiencing marijuana-related consequences. , 2015). In fact, about 30% of college students report past-year prevalence of marijuana use, and nearly 10% meet diagnostic criteria for cannabis use disorder (Caldeira et al., 2008;Johnston et al., 2015). In a recent study across 11 different U.S. universities, Pearson and colleagues (2017) found that between 15.5% and 38.7% (M = 26.2%) of college students report using marijuana in the past month. Further, marijuana-related negative consequences are prevalent with marijuana users experiencing approximately eight distinct negative consequences monthly (Pearson et al., 2017). Although there are several known risk (e.g., earlier age at first use and coping motives) and protective factors (e.g., self-regulation and female sex) of problematic marijuana use, research needs to go beyond examining only distal antecedents 1 and consider more proximal behaviors that may increase or decrease the negative consequences from using marijuana. Within the present study, we focus on marijuana protective behavioral strategies (PBS; Pedersen et al., 2016) as a proximal factor expected to a) relate to both frequency of marijuana use and marijuana-related negative consequences, and b) account for the effects of several known risk/ protective factors of problematic marijuana use.Stemming from a harm reduction focus in the alcohol field, much research has been conducted examining the use of alcohol PBS, defined as "behaviors that are used im-1 We refer to these variables as "distal antecedents" to marijuanarelated outcomes to distinguish them from more "proximal antecedents," which tend to be variables that are less stable, more malleable, and presumed to be more proximal in a causal chain leading to marijuan...