BACKGROUND
Breast cancer survivors experience long-term physical and psychological sequelae following primary treatment that negatively influence quality of life (QOL) and increase depressive symptoms. Group-based cognitive-behavioral stress management (CBSM) delivered post-surgery for early stage breast cancer was previously associated with better QOL over a 12-month follow-up, as well as with fewer depressive symptoms up to five years post-study enrollment. This 8–15 year (11-year median) follow-up of a previously conducted trial (#NCT01422551) evaluated whether women in this cohort receiving CBSM had fewer depressive symptoms and better QOL than controls at the 8–15 years follow-up.
METHODS
Women with stage 0-IIIb breast cancer were initially recruited 2–10 weeks post-surgery and randomized to a 10-week CBSM intervention or a 1-day psychoeducational control group. One hundred women (51 CBSM, 49 controls) were re-contacted 8–15 years post study enrollment to participate in a follow-up assessment. The Center for Epidemiologic Studies- Depression scale (CES-D) and the Functional Assessment of Cancer Therapy-Breast (FACT-B) were self-administered. Multiple regression was employed to evaluate group differences on the CES-D and FACT-B over and above effects of confounding variables.
RESULTS
Participants assigned to CBSM reported significantly lower depressive symptoms (d=0.63, 95% CI [0.56,0.70]), and better QOL (d=0.58, 95% CI [0.52,0.65]), above the effects of the covariates.
CONCLUSIONS
Women who received CBSM post-surgery for early stage breast cancer reported lower depressive symptoms and better QOL than the control group up to 15 years later. Early implementation of cognitive-behavioral interventions may influence long-term psychosocial functioning in breast cancer survivors.