It is well-established that the use of digital technologies can generate clear advantages for enterprises including cost savings, operational efficiency, IT resilience and scalability, easier access to new markets, and market effectiveness, amongst others. However, the adoption and use of digital technologies by rural businesses typically lags urban enterprises. This chapter introduces and defines the concept of the digital economy and digital business. It discusses the main benefits and challenges in the adoption and use of digital technologies by enterprises in general and by those in a rural context. The chapter concludes with a discussion of international frameworks and composite indices for measuring the adoption and use of digital technologies by businesses.