Measuring the Global Burden of Disease

Murray, Christopher J L; Lopez, Alan D

doi:10.1056/nejmra1201534

Cited by 1,588 publications

(1,169 citation statements)

References 48 publications

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“…of suicide was 2.2% in less severe outpatients and 8.6% in those with more severe depression and a history of hospitalization (Bostwick & Pankratz, 2000). Because of its high prevalence and resulting disability (major depression is classified as the second greatest cause of disability, adjusted for years of life, in developed countries) (Murray & Lopez, 1996). The concern in preventing recurrences of MDE is relevant and has been the target of research both with pharmacological treatment and psychotherapy (Antonuccio et al, 1995;Fava et al, 1996;Fava et al, 1998a;Fava et al, 1998b;Hollon et al, 2005).…”

Section: Epidemiological Aspectsmentioning

confidence: 99%

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Cognitive Behavioral Therapy for Depression

Sudak¹

2012

Psychiatric Clinics of North America

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Section: Epidemiological Aspectsmentioning

confidence: 99%

“…Depression has a substantial impact on the lives of patients and their families, significantly affecting their social and occupational lives as well as causing other functional impairments (Murray & Lopez, 1996).…”

Section: Introductionmentioning

confidence: 99%

Cognitive Behavioral Therapy for Depression

Sudak¹

2012

Psychiatric Clinics of North America

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“…Chronic liver diseases affect more than 500 million people worldwide and cause 2% of all deaths 1, 2. In addition, liver‐related deaths are progressively increasing, with cirrhosis anticipated to be the twelfth leading cause of death in 2020 3.…”

Section: Introductionmentioning

confidence: 99%

Liver tissue engineering: From implantable tissue to whole organ engineering

Mazza

Al‐Akkad

Rombouts

et al. 2017

Hepatology Communications

113

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The term “liver tissue engineering” summarizes one of the ultimate goals of modern biotechnology: the possibility of reproducing in total or in part the functions of the liver in order to treat acute or chronic liver disorders and, ultimately, create a fully functional organ to be transplanted or used as an extracorporeal device. All the technical approaches in the area of liver tissue engineering are based on allocating adult hepatocytes or stem cell‐derived hepatocyte‐like cells within a three‐dimensional structure able to ensure their survival and to maintain their functional phenotype. The hosting structure can be a construct in which hepatocytes are embedded in alginate and/or gelatin or are seeded in a pre‐arranged scaffold made with different types of biomaterials. According to a more advanced methodology termed three‐dimensional bioprinting, hepatocytes are mixed with a bio‐ink and the mixture is printed in different forms, such as tissue‐like layers or spheroids. In the last decade, efforts to engineer a cell microenvironment recapitulating the dynamic native extracellular matrix have become increasingly successful, leading to the hope of satisfying the clinical demand for tissue (or organ) repair and replacement within a reasonable timeframe. Indeed, the preclinical work performed in recent years has shown promising results, and the advancement in the biotechnology of bioreactors, ex vivo perfusion machines, and cell expansion systems associated with a better understanding of liver development and the extracellular matrix microenvironment will facilitate and expedite the translation to technical applications. (Hepatology Communications 2018;2:131–141)

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“…1 , 2 Early detection, before clinical expression of progressive weight gain, is the most reliable way to prevent morbidity, mortality and its implications. 1 , 2 Therefore, any marker or high-risk signal that reveals these diseases before overt clinical appearance would be foremost valuable. One of these initial abnormalities could be insulin resistance (IR), a primary feature linked to early stages of obesity, type 2 diabetes, hypertension, dyslipidemia, cancer, and other illnesses.…”

Section: Introductionmentioning

confidence: 99%

Acanthosis nigricans in the knuckles: An early, accessible, straightforward, and sensitive clinical tool to predict insulin resistance

González-Saldivar

Rodríguez-Gutiérrez

Treviño-Alvarez

et al. 2018

Dermato-Endocrinology

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Any clinical/biochemical marker revealing obesity or diabetes before their appearance is valuable. Insulin resistance (IR) is present in both disorders many years before occurrence. Accordingly, we determined whether acanthosis nigricans (AN) in the knuckles is associated to higher insulin and homeostasis model assessment for estimated insulin resistance (HOMA-IR) index values, and assessed the influence of body-mass index (BMI) and the diagnostic performance of AN in the knuckles to detect IR. In this cross-sectional controlled study, we included men or women, 18 to 23 years old, with or without AN in the knuckles. In 149 cases with AN in the knuckles and 145 controls, fasting insulin was higher in cases (13.45 µU/mL ± 7.8 vs. 8.59 µU/mL ± 3.63, P < .001, respectively). Mean HOMA-IR index was also higher (2.86 ± 1.68 vs. 1.78 ± 0.77, P < .001). A significant increase in fasting insulin and HOMA-IR values between and within BMI groups from normal through obese category was identified in controls and cases. By multivariate regression analysis, cases with normal BMI were significantly associated to a HOMA-IR ≥2.5 (OR = 3.09, CI95% = 1.75–5.48, P = .001). A model of AN in the knuckles, normal BMI, and increased waist circumference allowed identifying 2 out of 3 cases with HOMA-IR index ≥2.5. AN in the knuckles could be addressed with two aims: as an easy, accessible, and costless diagnostic tool suggesting hyperinsulinemia secondary to IR, and, an early marker of IR even in the absence of overweight or obesity.

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Measuring the Global Burden of Disease

Cited by 1,588 publications

References 48 publications

Cognitive Behavioral Therapy for Depression

Cognitive Behavioral Therapy for Depression

Liver tissue engineering: From implantable tissue to whole organ engineering

Acanthosis nigricans in the knuckles: An early, accessible, straightforward, and sensitive clinical tool to predict insulin resistance

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