Measuring the Interaction of Human Secretory Glycoproteins with Oral Bacteria

Eggert, F M; Maenz, Lynn; Tam, Y.

doi:10.1177/00220345870660024501

Cited by 12 publications

(9 citation statements)

References 17 publications

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“…Mansheim et al (1980) evaluated salivary IgA levels to Bacteroides asaccharolyticus (now known as Porphyromonas gingivalis) in 8 patients with RPP and 3 patients with JP, and found that antibody levels in saliva samples from patients were not significantly different from those of agematched controls. Eggert et al (1987) reported that saliva from treated periodontitis patients had higher IgA and IgG levels than did saliva from control subjects. These higher antibody levels were observed for periodontal pathogens (P. gingivalis and Treponema denticola), but also for the normal inhabitant of the oral cavity Streptococus salivarius.…”

Section: Specific Immunoglobulins In Salivamentioning

confidence: 99%

Analysis of saliva for periodontal diagnosis

Kaufman

Lamster

2000

J Clinic Periodontology

337

293

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A number of markers show promise as sensitive measures of disease and the effectiveness of therapy. At this time, host-derived enzymes and other inflammatory mediators orginating from the gingival crevice appear to hold the greatest promise as salivary diagnostic tests for periodontal disease. Longer-term longitudinal studies, however, are required to establish the relationship between specific markers and progression of periodontal disease. Furthermore, analysis of saliva may offer a cost-effective approach to assessment of periodontal disease in large populations.

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Section: Specific Immunoglobulins In Salivamentioning

confidence: 99%

Analysis of saliva for periodontal diagnosis

Kaufman

Lamster

2000

J Clinic Periodontology

337

293

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“…Eggert et al . [13] reported that saliva from treated periodontitis patients had higher IgA and IgG levels to periodontal pathogens porphyromonas. gingivalis and Treponema.…”

Section: Salivary Markers Of Periodontal Diseasesmentioning

confidence: 99%

Saliva: A diagnostic biomarker of periodontal diseases

Patil

2011

J Indian Soc Periodontol

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Early detection of disease plays a crucial role in successful therapy. Early diagnosis and management reduces the severity and possible complications of the disease process. To overcome this challenge, medical researchers are devoted to finding molecular disease biomarkers that reveal a hidden lethal threat before the disease becomes complicated. Saliva, an important physiologic fluid, containing a highly complex mixture of substances, is rapidly gaining popularity as a diagnostic tool. Periodontal disease is a chronic disease of the oral cavity comprising a group of inflammatory conditions affecting the supporting structures of the dentition. In the field of periodontology, traditional clinical criteria are often insufficient for determining sites of active disease, for monitoring the response to therapy, or for measuring the degree of susceptibility to future disease progression. Saliva, as a mirror of oral and systemic health, is a valuable source for clinically relevant information because it contains biomarkers specific for the unique physiologic aspects of periodontal diseases. This review highlights the various potentials of saliva as a diagnostic biomarker for periodontal diseases.

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“…Some studies observed no change in the levels of salivary IgA antibodies to Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans, and Bacteroides asaccharolyticus between healthy subjects and subjects with periodontal diseases (182,292). Other studies reported an increased level of IgA antibodies to A. actinomycetemcomitans in some patients with adult and juvenile periodontitis (124,418,445). Others observed that treatment of gingivitis and periodontitis by root scaling and polishing was accompanied by an increased level of salivary IgA antibodies not only against suspected pathogens such as Actinomyces naeslundii genospecies 2, A. actinomycetemcomitans, P. gingivalis, and Treponema denticola but also against S. salivarius (124,418,504).…”

Section: Correlation Between Secretory Iga and Oral Diseasesmentioning

confidence: 99%

Oral Microbial Ecology and the Role of Salivary Immunoglobulin A

Marcotte¹,

Lavoie

1998

Microbiol Mol Biol Rev

439

294

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SUMMARY In the oral cavity, indigenous bacteria are often associated with two major oral diseases, caries and periodontal diseases. These diseases seem to appear following an inbalance in the oral resident microbiota, leading to the emergence of potentially pathogenic bacteria. To define the process involved in caries and periodontal diseases, it is necessary to understand the ecology of the oral cavity and to identify the factors responsible for the transition of the oral microbiota from a commensal to a pathogenic relationship with the host. The regulatory forces influencing the oral ecosystem can be divided into three major categories: host related, microbe related, and external factors. Among host factors, secretory immunoglobulin A (SIgA) constitutes the main specific immune defense mechanism in saliva and may play an important role in the homeostasis of the oral microbiota. Naturally occurring SIgA antibodies that are reactive against a variety of indigenous bacteria are detectable in saliva. These antibodies may control the oral microbiota by reducing the adherence of bacteria to the oral mucosa and teeth. It is thought that protection against bacterial etiologic agents of caries and periodontal diseases could be conferred by the induction of SIgA antibodies via the stimulation of the mucosal immune system. However, elucidation of the role of the SIgA immune system in controlling the oral indigenous microbiota is a prerequisite for the development of effective vaccines against these diseases. The role of SIgA antibodies in the acquisition and the regulation of the indigenous microbiota is still controversial. Our review discusses the importance of SIgA among the multiple factors that control the oral microbiota. It describes the oral ecosystems, the principal factors that may control the oral microbiota, a basic knowledge of the secretory immune system, the biological functions of SIgA, and, finally, experiments related to the role of SIgA in oral microbial ecology.

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Measuring the Interaction of Human Secretory Glycoproteins with Oral Bacteria

Cited by 12 publications

References 17 publications

Analysis of saliva for periodontal diagnosis

Analysis of saliva for periodontal diagnosis

Saliva: A diagnostic biomarker of periodontal diseases

Oral Microbial Ecology and the Role of Salivary Immunoglobulin A

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