The increasing mobility of population and industry is the main problem in this study, so it will affect the spatial pattern in the distribution of pollutants. The parameters to measure air quality are Sulfur Dioxide and Nitrogen Dioxide. This study aims to (1) analyze air quality distribution patterns with SO2 and NO2 concentration parameters in the DKI Jakarta area in 2021, (2) analyze ambient air quality distribution patterns based on air quality threshold values, and (3) analyze the spatial distribution of SO2 and NO2 in the DKI Jakarta area in 2021. The data used for this research is the average concentration data of SO2 and NO2 pollutants in DKI Jakarta in 2021. This research uses the interpolation method using Inverse Distance Weighting and Getis-Ord Gi*. The results of this research show that the concentration of pollutants that have been interpolated using Inverse Distance Weighting produces higher NO2 than SO2. From the interpolated image, a Hot Spot analysis (Getis-Ord Gi*) was conducted. This analysis showed significant clustering of nearest neighbors, with high concentrations of SO2 in East Jakarta and NO2 in West Jakarta. Therefore, air quality needs to be monitored and managed to maintain environmental stability.