Measuring the timeliness of childhood vaccinations: Using cohort data and routine health records to evaluate quality of immunisation services

Walton, Suzanne; Cortina‐Borja, Mario; Dezateux, Carol; Griffiths, Lucy J; Tingay, Karen; Akbari, Ashley; Bandyopadhyay, Amrita; Lyons, Ronan A; Bedford, Helen

doi:10.1016/j.vaccine.2017.10.085

Cited by 53 publications

(41 citation statements)

References 17 publications

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“…When vaccine coverage is low or when timely compliance with the full series is not achieved, infants are left vulnerable to infectious diseases and their negative impact on their health. 17 The findings of this study are in line with other studies from the US which reported suboptimal coverage of rotavirus vaccination despite the availability of two effective vaccines. Coverage and compliance with two-dose Rotarix were, however, higher than with three-dose RotaTeq.…”

Section: Discussionsupporting

confidence: 91%

Vaccine coverage and compliance in Mexico with the two-dose and three-dose rotavirus vaccines

Luna-Casas¹,

Juliao

Carreño-Manjarrez³

et al. 2018

Human Vaccines & Immunotherapeutics

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Worldwide, rotavirus infection has been a leading cause of severe diarrhea morbidity and mortality. Two rotavirus vaccines have been used in the National Immunization Program (NIP) in Mexico; two-dose Rotarix from 2006 to 2011 and three-dose RotaTeq since 2011. This study assessed coverage (receiving at least one dose or full dose series) in eligible infants, compliance (% completing dose series and % completing series on schedule) in eligible infants vaccinated with Rotarix (2010) versus RotaTeq (2012), using Mexican Social Security Institute data nationwide and by regions.In 2010, 80.7% received at least one dose of Rotarix, 75.6% received both doses and 57.0% received both doses on schedule. In 2012, 85.7% received at least one dose of RotaTeq, 61.0% received all three doses and 43.2% received all three doses on schedule. More eligible infants received all doses with Rotarix versus RotaTeq (p < 0.001). Among infants vaccinated with Rotarix versus RotaTeq, 93.7% versus 71.1% completed full series (p < 0.001), and 75.5% versus 70.9% completed full series on schedule (p = 0.105), respectively. The full series coverage and compliance decreased in all regions with RotaTeq compared with Rotarix. In conclusion, rotavirus vaccination has successfully reduced morbidity and mortality in children under 5 years in Mexico. This study found significant differences in full series coverage and compliance among infants and a higher proportion of completed scheduled at an earlier age in Mexico when comparing a two-dose vaccine in 2010 with a three-dose vaccine in 2012. Such differences might need to be taken into consideration to maximize NIP benefits, including early protection of the rotavirus vaccination program.

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Section: Discussionsupporting

confidence: 91%

Vaccine coverage and compliance in Mexico with the two-dose and three-dose rotavirus vaccines

Luna-Casas¹,

Juliao

Carreño-Manjarrez³

et al. 2018

Human Vaccines & Immunotherapeutics

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“…[6] A further recent study using linked data from Wales also found similar results with respect to infants of multiparous mothers. [20] Here we report, on a significantly larger cohort of 1.9 million births through integrating population-based perinatal, birth and immunisation datasets, on-time uptake of DTP infant doses in population subgroups, many of which also have been previously identified as significant factors for delayed vaccination. Our findings confirm those of the systematic review, with differences in on-time uptake between infants of multiparous versus primiparous mothers as high as 23%.…”

Section: Discussionmentioning

confidence: 94%

Assessment of on-time vaccination coverage in population subgroups: A record linkage cohort study

Moore

Fathima

Gidding

et al. 2018

Vaccine

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Reported infant vaccination coverage at age 12 months in Australia is >90%. On-time coverage of the 2-4-6 month schedule and coverage in specific populations is rarely reported. We conducted a population-based cohort study of 1.9 million Australian births, 1996-2012, combining individual birth and perinatal records with immunisation records through probabilistic linkage. We assessed on-time coverage across 13 demographic and perinatal characteristics of diphtheria-tetanus-pertussis vaccines (DTP) defined as vaccination 14 days prior to the scheduled due date, to 30 days afterwards. On-time DTP vaccination coverage in non-Aboriginal infants was 88.1% for the 2-month dose, 82.0% for 4-month dose, and 76.7% for 6-month dose; 3-dose coverage was 91.3% when assessed at 12 months. On-time DTP coverage for Aboriginal infants was 77.0%, 66.5%, and 61.0% for the 2-4-6 month dose; 3-dose coverage at 12 months was 79.3%. Appreciable differences in on-time coverage were observed across population subgroups. On-time coverage in non-Aboriginal infants born to mothers with ≥3 previous pregnancies was 62.5% for the 6-month dose (47.9% for Aboriginal infants); up to 23.5 percentage points lower than for first-borns. Infants born to mothers who smoked during pregnancy had coverage 8.7-10.3 percentage points lower than infants born to non-smoking mothers for the 4- and 6-month dose. A linear relationship was apparent between increasing socio-economic disadvantage and decreasing on-time coverage. On-time coverage of the 2-4-6 month schedule is only 50-60% across specific population subgroups representing a significant avoidable public health risk. Aboriginal infants, multiparous mothers, and those who are socio-economically disadvantaged are key groups most likely to benefit from targeted programs addressing vaccine timeliness.

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“…Demographically, our linked study population of consenting, linked singletons do not noticeably differ from the entire MCS population in many aspects, which suggests a relatively representative sample within the MCS cohort. This is particularly relevant for the disorder-specific aspects of our study (see, to date, [9][10]). The subpopulations for the different linked health datasets were also not markedly different from the base study population.…”

Section: Key Resultsmentioning

confidence: 99%

“…Linkage to longitudinal routine health records has the ability to provide a rich research resource for further studies. The resulting linked cohort has been used to better understand timeliness of childhood vaccination [9] and comparing GP-rated versus maternal-reported history of childhood wheezing [10].…”

Section: Key Resultsmentioning

confidence: 99%

“…This article describes the experiences of linking a UKwide longitudinal cohort study, the Millennium Cohort Study (MCS), to routine health records for consenting participants. The resulting linked datasets have been used to examine the health outcomes of childhood obesity, asthma, infections and injuries, and patterns of health service utilisation, including timeliness of immunisation in childhood [9,10].…”

Section: Introductionmentioning

confidence: 99%

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Record linkage to enhance consented cohort and routinely collected health data from a UK birth cohort

Tingay

Bandyopadhyay

Griffiths

et al. 2019

IJPDS

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BackgroundIn longitudinal health research, combining the richness of cohort data to the extensiveness of routine data opens up new possibilities, providing information not available from one data source alone. In this study, we set out to extend information from a longitudinal birth cohort study by linking to the cohort child’s routine primary and secondary health care data. The resulting linked datasets will be used to examine health outcomes and patterns of health service utilisation for a set of common childhood health problems. We describe the experiences and challenges of acquiring and linking electronic health records for participants in a national longitudinal study, the UK Millennium Cohort Study (MCS). MethodWritten parental consent to link routine health data to survey responses of the MCS cohort member, mother and her partner was obtained for 90.7% of respondents when interviews took place at age seven years in the MCS. Probabilistic and deterministic linkage was used to link MCS cohort members to multiple routinely-collected health data sources in Wales and Scotland. ResultsOverall linkage rates for the consented population using country-specific health service data sources were 97.6% for Scotland and 99.9% for Wales. Linkage rates between different health data sources ranged from 65.3% to 99.6%. Issues relating to acquisition and linkage of data sources are discussed. ConclusionsLinking longitudinal cohort participants with routine data sources is becoming increasingly popular in population data research. Our results suggest that this is a valid method to enhance information held in both sources of data.

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Measuring the timeliness of childhood vaccinations: Using cohort data and routine health records to evaluate quality of immunisation services

Cited by 53 publications

References 17 publications

Vaccine coverage and compliance in Mexico with the two-dose and three-dose rotavirus vaccines

Vaccine coverage and compliance in Mexico with the two-dose and three-dose rotavirus vaccines

Assessment of on-time vaccination coverage in population subgroups: A record linkage cohort study

Record linkage to enhance consented cohort and routinely collected health data from a UK birth cohort

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