The purpose of this article is to analyze the internal and external barriers experienced by university students of the Technological Institute of Sonora (ITSON) for the development of entrepreneurship. The study is focused on a sample of 733 students from the areas of engineering, administrative sciences, and social sciences. The field work was carried out during the months of May to September 2018. The controlled statistical technique for data analysis was the structural equation model (SEM) with the support of SMARTPLS software version 3.2.8. The results have revealed that internal creativity barriers are the ones that most negatively impact the entrepreneurial passion of ITSON university students. This research contributes to the development of entrepreneurship literature from the area of psychology and business sciences through planned behavior theory, cognitive theory, and self-determination.