Mebendazole dietary supplementation controls Monogenoidea (Platyhelminthes: Dactylogyridae) and does not alter the physiology of the freshwater fish Colossoma macropomum (Cuvier, 1818)

Chagas, Edsandra Campos; Araújo, Lucelle Dantas de; Martins, Maurício Laterça; Gomes, Levy Carvalho; Malta, José Celso de Oliveira; Varella, Angela B.; Jerônimo, Gabriela Tomas

doi:10.1016/j.aquaculture.2016.06.022

Cited by 15 publications

(12 citation statements)

References 43 publications

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“…Of note, the experiment employing mebendazole particles did not cause mortality or lethargy, neither physical aspect and behavior changes, confirming good safety of the drug as described elsewhere. 54 These latter results may suggest that concentrations of mebendazole were insufficient to completely eliminate the parasites. However, one has to further consider that digenetic trematodes are especially difficult to treat because this class of parasites is generally absent in γ-amino-butyric acid (GABA), which is a main target of antiparasitic drugs, leading to flaccid paralysis of parasites.…”

Section: Methodsmentioning

confidence: 99%

Targeted Drug Delivery and Treatment of Endoparasites with Biocompatible Particles of pH-Responsive Structure

et al. 2018

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Biomaterials conceived for vectorization of bioactives are currently considered for biomedical, biological, and environmental applications. We have produced a pH-sensitive biomaterial composed of natural source alginate and chitosan polysaccharides for application as a drug delivery system via oral administration. The composite particle preparation was in situ monitored by means of isothermal titration calorimetry. The strong interaction established between the macromolecules during particle assembly led to 0.60 alginate/chitosan effective binding sites with an intense exothermic effect and negative enthalpy variation on the order of a thousand kcal/mol. In the presence of model drugs mebendazole and ivermectin, with relatively small and large structures, respectively, mebendazole reduced the amount of chitosan monomers available to interact with alginate by 27%, which was not observed for ivermectin. Nevertheless, a state of intense negative Gibbs energy and large entropic decrease was achieved, providing evidence that formation of particles is thermodynamically driven and favored. Small-angle X-ray scattering provided further evidence of similar surface aspects independent of the presence of drug. The physical responses of the particles to pH variation comprise partial hydration, swelling, and the predominance of positive surface charge in strong acid medium, whereas ionization followed by deprotonation leads to compaction and charge reversal rather than new swelling in mild and slightly acidic mediums, respectively. In vivo performance was evaluated in the treatment of endoparasites in Corydoras fish. Systematically with a daily base oral administration, particles significantly reduced the infections over 15 days of treatment. The experiments provide evidence that utilizing particles granted and boosted the action of the antiparasitic drugs, leading to substantial reduction or elimination of infection. Hence, the pH-responsive particles represent a biomaterial with prominent characteristics that is promising for the development of targeted oral drug delivery.

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Section: Methodsmentioning

confidence: 99%

Targeted Drug Delivery and Treatment of Endoparasites with Biocompatible Particles of pH-Responsive Structure

et al. 2018

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“…The niche induces adaptations in physiology, between sexes, during gonadal development, and in relation to nutrition and seasonal variations (Campbell & Murru, 1990;Sharma, Akhtar, Pandey, Singh & Singh, 2017 Acari-canoa had higher blood glucose levels compared to the other acaris. Blood glucose concentration is regarded as a reliable indicator of physiological stress in fish (Neves et al, 2016;Chagas et al, 2016), and is directly related to the mode of life and metabolic activity of a fish (Ranzani-Paiva & Silva-Souza, 2004). Acari-canoa appears to have a more active swimming behaviour, and presumably, requires greater energy reserves to supply its metabolism compared to the other three studied species.…”

Section: Results and Discusionmentioning

confidence: 99%

<b>Haematological assessment of four amazonian ornamental armoured catfish (Teleostei, Loricariidae)

Neves

Barbas

Couto

et al. 2018

Acta Sci. Biol. Sci.

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ABSTRACT. The aim of this study was to characterize the haematological profile of four Amazonian ornamental freshwater armoured catfish: acari-bola (Peckoltia oligospila -L06), acari-pleco (Cochliodon sp. -L145), acari-canoa (Lasiancistrus saetiger -L323) and acari-assacu (Pseudocanthicus spinosus -L160). The highest blood glucose levels (72.47 ± 28.7 mg dL ) were recorded for acari-canoa. The acari-bola and acari-pleco presented similar concentrations of total plasma protein (TPP) (7.96 ± 1.8 and 7.93 ± 1.8 g dL -1, respectively) against lower TPP concentrations observed in acari-canoa (4.87 ± 1.5 g dL -1) and acariassacu (6.55 ± 1.5 g dL -1). The acari-assacu had lower total haemoglobin concentration (5.88 ± 1.7 g dL -1) and haematocrit (12.66 ± 4.6%). No interspecific differences were observed in mean corpuscular volume (MCV) and mean corpuscular haemoglobin concentration (MCHC). The acari-pleco and acari-assacu presented the highest counts for neutrophils (4142.42 ± 3280.1 cel. μL ), respectively. The haematological profiles were similar to those reported in the literature for freshwater fish and the interspecific differences observed were discussed.

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“…The highest producing states are Rondônia, Maranhão, Pará and Amazonas (Peixe BR, 2020). Because of intensive production systems and their high stocking densities, tambaqui production fell in 2018 by 4.7%, when compared to the previous year (Peixe BR, 2019), and imbalance in the fish–pathogen–environment relationship culminates in elevated susceptibility to diseases (Chagas et al., 2016). According to Tavares‐Dias and Martins (2017), among the parasites, the most found in tambaqui are the protozoa ( Chilodonella sp., Trichodina sp.…”

Section: Introductionmentioning

confidence: 99%

Effect of a food additive in the control of the acanthocephalanNeoechinorhynchus buttneraeinColossoma macropomum

et al. 2020

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Mebendazole dietary supplementation controls Monogenoidea (Platyhelminthes: Dactylogyridae) and does not alter the physiology of the freshwater fish Colossoma macropomum (Cuvier, 1818)

Cited by 15 publications

References 43 publications

Targeted Drug Delivery and Treatment of Endoparasites with Biocompatible Particles of pH-Responsive Structure

Targeted Drug Delivery and Treatment of Endoparasites with Biocompatible Particles of pH-Responsive Structure

<b>Haematological assessment of four amazonian ornamental armoured catfish (Teleostei, Loricariidae)

Effect of a food additive in the control of the acanthocephalanNeoechinorhynchus buttneraeinColossoma macropomum

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