Mécanismes de division cellulaire asymétrique

SummaryEstablishment of cellular polarity is one of the key events during oocyte maturation. Inscuteable (Insc) has been identified as a key regulator of cell polarity during asymmetric division in Drosophila. However, the function of its evolutionarily conserved mammalian homologue, mInscuteable (mInsc), in mouse meiotic maturation is not clear. In this study, we investigated the roles of mInsc in mouse oocyte maturation. mInsc was detected at all stages of oocyte maturation. The protein level of mInsc was slightly higher at the germinal vesicle breakdown (GVBD) stage and remained constant during mouse oocyte maturation. The subcellular localization of mInsc overlapped with spindle microtubules. Disruption of microtubules and microfilaments caused changes in the localization of mInsc. Depletion or overexpression of mInsc significantly decreased the maturation rates of mouse oocytes. Depletion of mInsc significantly affected asymmetric division, spindle assembly, alignments of chromosomes and actin cap formation. Taken together, our results demonstrated that mInsc regulates meiotic spindle organization during mouse meiotic maturation.

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Le fuseau mitotique, le centrosome et le cancer : trouvez l’intrus !

Romé

Prigent

Giet

2010

Med Sci (Paris)

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Mécanismes de division cellulaire asymétrique

Cited by 6 publications

References 38 publications

A Phase Transition for Large Values of Bifurcating Autoregressive Models

A Phase Transition for Large Values of Bifurcating Autoregressive Models

mInscuteable regulates meiotic spindle organization during mouse oocyte meiotic maturation

Le fuseau mitotique, le centrosome et le cancer : trouvez l’intrus !

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