Mechanic’s hand; is it a prodromic sign of disease relapse of anti-synthetase syndrome; a case report

Abstract

Background Anti-synthetase syndrome is the collection of myositis and/or interstitial lung disease with the presence of various antibodies directed against an aminoacyl transfer RNA synthetase. Anti Jo − 1 antibody is the commonest of these antibodies and its presence is characteristically associated with the dermatological manifestation of mechanic’s hands. However, in the absence of other features, whether the presence of mechanic’s hands could be considered as a prodromic sign of disease relapse is not proven. We would like to present a patient who developed mechanic’s hands and subsequently went on to have recurrence in her myositis. Case presentation A 45-year-old female initially presented with a progressive proximal muscle weakness. Her muscle enzymes were elevated, EMG and biopsy were also in keeping with an inflammatory myositis. Subsequently she was found to have an interstitial lung disease with a non-specific interstitial pneumonitis pattern radiologically. Her anti Jo-1 was positive. However, she did not have any dermatological manifestations at the time. With immunosuppressive therapy she achieved remission which lasted for about 2 years. Then she developed fissuring and cracking of the palms and fingers suggestive of mechanic’s hands without any muscle pain, weakness and elevation of muscle enzymes. A few months later she did develop muscle pain, weakness and elevation of muscle enzymes heralding a disease relapse. Conclusion The presence of mechanic’s hands without other features should be considered as a prodromic sign of disease relapse.

Mechanic Hands/Hiker Feet in a Patient With Amyopathic Dermatomyositis and Interstitial Lung Disease

“…29 Anti-Jo-1 antibody is the most common among these antibodies, and, like DM, its presence is characteristically associated with MH (40%-80% of cases). 1,3,32 Other associations with anti-Jo-1-positive ASS include nonerosive arthritis and Raynaud phenomenon. 3,4,32 There is a noticeable overlap between ASS and DM; however, our patient was negative for antiaminoacyl transfer RNA synthetase antibodies, a required criterion to diagnose ASS.…”

“…1,3,32 Other associations with anti-Jo-1-positive ASS include nonerosive arthritis and Raynaud phenomenon. 3,4,32 There is a noticeable overlap between ASS and DM; however, our patient was negative for antiaminoacyl transfer RNA synthetase antibodies, a required criterion to diagnose ASS. MH/HF has also less commonly been reported in association with other rheumatologic conditions, including SLE, scleroderma, mixed connective tissue disease, and druginduced ASS.…”

“…1,3,32 Other associations with anti-Jo-1–positive ASS include nonerosive arthritis and Raynaud phenomenon. 3,4,32…”

“…29 Anti-Jo-1 antibody is the most common among these antibodies, and, like DM, its presence is characteristically associated with MH (40%–80% of cases). 1,3,32 Other associations with anti-Jo-1–positive ASS include nonerosive arthritis and Raynaud phenomenon. 3,4,32…”