Mechanical Affective Touch Therapy (MATT) for Anxiety Disorders: Effects on Resting State Functional Connectivity

Gonsalves, Meghan A.; Beck, Quincy; Fukuda, Andrew M.; Tirrell, Eric; Kokdere, Fatih; Kronenberg, Eugenia F.; Iadarola, Nicolas D.; Hagberg, Sean; Carpenter, Linda L.; Barredo, Jennifer

doi:10.1016/j.brs.2021.10.137

Cited by 1 publication

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“…Meanwhile, integration of information inputs in the insula provides the prediction of a combination of pain, perceptual errors, or a variety of other current conditions (Geuter et al, 2017 ; Centanni et al, 2021 ). The integration of emotional and somatosensory signals is a crucial function of the insula (Gonsalves et al, 2021 ). Previous studies have confirmed that enhanced nociceptive sensitization in patients with chronic pain may be associated with overlapping pain activation in the insula (Ploghaus et al, 2001 ; Zhuo, 2016 ).…”

Section: Discussionmentioning

confidence: 99%

“…This, in turn, may shift attention to pain-induced central changes such as functional brain connectivity, abnormal activation of associated brain regions, and even large-scale brain network analysis. Concomitantly, we can optimize the clinical questionnaire evaluation system to determine more concordance with rsFC to help predict patient clinical symptoms and psychological status (Gonsalves et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

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Neuroplasticity of pain processing and motor control in CAI patients: A UK Biobank study with clinical validation

Li¹,

Xue²,

Xu³

et al. 2023

Front. Mol. Neurosci.

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BackgroundPain plays an important role in chronic ankle instability (CAI), and prolonged pain may be associated with ankle dysfunction and abnormal neuroplasticity.PurposeTo investigate the differences in resting-state functional connectivity among the pain-related brain regions and the ankle motor-related brain regions between healthy controls and patients with CAI, and explore the relationship between patients' motor function and pain.Study designA cross-database, cross-sectional study.MethodsThis study included a UK Biobank dataset of 28 patients with ankle pain and 109 healthy controls and a validation dataset of 15 patients with CAI and 15 healthy controls. All participants underwent resting-state functional magnetic resonance imaging scanning, and the functional connectivity (FC) among the pain-related brain regions and the ankle motor-related brain regions were calculated and compared between groups. The correlations between the potentially different functional connectivity and the clinical questionnaires were also explored in patients with CAI.ResultsThe functional connection between the cingulate motor area and insula significantly differed between groups in both the UK Biobank (p = 0.005) and clinical validation dataset (p = 0.049), which was also significantly correlated with Tegner scores (r = 0.532, p = 0.041) in patients with CAI.ConclusionA reduced functional connection between the cingulate motor area and the insula was present in patients with CAI, which was also directly correlated with reduction in the level of patient physical activity.

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