2014
DOI: 10.1007/s00424-014-1532-0
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Mechanical allodynia

Abstract: Mechanical allodynia (other pain) is a painful sensation caused by innocuous stimuli like light touch. Unlike inflammatory hyperalgesia that has a protective role, allodynia has no obvious biological utility. Allodynia is associated with nerve damage in conditions such as diabetes, and is likely to become an increasing clinical problem. Unfortunately, the mechanistic basis of this enhanced sensitivity is incompletely understood. In this review, we describe evidence for the involvement of candidate mechanosensi… Show more

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Cited by 115 publications
(81 citation statements)
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“…Thus, pain is encoded through a hybrid mechanism that combines Perl’s specificity and Wall’s pattern theories, a mechanism recently referred to as the population coding theory (Ma, 2010, 2012; Prescott et al, 2014). Clinically, mechanical pain treatment represents a big challenge (Lolignier et al, 2014). Our study suggests that drugs targeted at reducing excitatory output from SOM neurons or enhancing inhibitory output from Dyn neurons could be ideally used to attenuate mechanical allodynia, without affecting the senses of temperature and touch that are vital for daily life.…”
Section: Discussionmentioning
confidence: 99%
“…Thus, pain is encoded through a hybrid mechanism that combines Perl’s specificity and Wall’s pattern theories, a mechanism recently referred to as the population coding theory (Ma, 2010, 2012; Prescott et al, 2014). Clinically, mechanical pain treatment represents a big challenge (Lolignier et al, 2014). Our study suggests that drugs targeted at reducing excitatory output from SOM neurons or enhancing inhibitory output from Dyn neurons could be ideally used to attenuate mechanical allodynia, without affecting the senses of temperature and touch that are vital for daily life.…”
Section: Discussionmentioning
confidence: 99%
“…In many cases, it appears to involve aberrant sensitivity to mechanical force at the level of cutaneous mechanoreceptors or primary afferent neurons. Mechanical allodynia, associated with several neuropathies, is the disease where normally innocuous stimuli are perceived as excruciatingly painful (52). No specific treatments are available beyond palliative measures.…”
Section: Biological Aspects Of Piezo2mentioning
confidence: 99%
“…It is the underlying mechanism for both touch and hearing and is known to have roles in cancer, allodynia heart and vascular disease12. The plasma membrane is thought to couple force directly with effector molecules such as mechanosensitive ion channels345 and organize mechanosensitive proteins including focal adhesion proteins6.…”
mentioning
confidence: 99%