Mechanical Amplification Exhibited by Quiescent Saccular Hair Bundles

Roongthumskul, Yuttana; Bozovic, Dolores

doi:10.1016/j.bpj.2014.11.009

Cited by 4 publications

(2 citation statements)

References 31 publications

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“…Our theoretical prediction thus proposes an additional potential mechanism of tuning a system of oscillatory hair bundles closer to criticality via mechanical coupling. Other physical quantities have been proposed to poise an uncoupled hair bundle near the verge of an instability; examples include mass, elastic loadings, and a stationary offset on the bundle’s resting position imposed by its surrounding structure ( 12 , 15 , 32 ). A combination of these may be utilized as a mechanism that effectively brings an in vivo system of hair bundles near the critical point.…”

Section: Discussionmentioning

confidence: 99%

Dynamics of Mechanically Coupled Hair-Cell Bundles of the Inner Ear

Roongthumskul

Faber

Bozovic

2021

Biophysical Journal

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The high sensitivity and effective frequency discrimination of sound detection performed by the auditory system rely on the dynamics of a system of hair cells. In the inner ear, these acoustic receptors are primarily attached to an overlying structure that provides mechanical coupling between the hair bundles. Although the dynamics of individual hair bundles has been extensively investigated, the influence of mechanical coupling on the motility of the system of bundles remains underdetermined. We developed a technique of mechanically coupling two active hair bundles, enabling us to probe the dynamics of the coupled system experimentally. We demonstrated that the coupling could enhance the coherence of hair bundles’ spontaneous oscillation, as well as their phase-locked response to sinusoidal stimuli, at the calcium concentration in the surrounding fluid near the physiological level. The empirical data were consistent with numerical results from a model of two coupled nonisochronous oscillators, each displaying a supercritical Hopf bifurcation. The model revealed that a weak coupling can poise the system of unstable oscillators closer to the bifurcation by a shift in the critical point. In addition, the dynamics of strongly coupled oscillators far from criticality suggested that individual hair bundles may be regarded as nonisochronous oscillators. An optimal degree of nonisochronicity was required for the observed tuning behavior in the coherence of autonomous motion of the coupled system.

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Section: Discussionmentioning

confidence: 99%

Dynamics of Mechanically Coupled Hair-Cell Bundles of the Inner Ear

Roongthumskul

Faber

Bozovic

2021

Biophysical Journal

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show abstract

“…Our theoretical prediction thus proposes an additional potential mechanism of tuning a system of oscillatory hair bundles closer to criticality via mechanical coupling. Other proposed physical quantities have focused on poising an uncoupled hair bundle near the verge of an instability; examples include mass, elastic loadings, and a stationary offset on the bundle's resting position imposed by its surrounding structure [12,15,32]. A combination of these may be utilized as a mechanism that effectively brings an in vivo system of hair bundles near the critical point.…”

Section: Discussionmentioning

confidence: 99%

Dynamics of mechanically coupled hair-cell bundles of the inner ear

Roongthumskul

Faber

Bozovic

2020

Preprint

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The high sensitivity and effective frequency discrimination of sound detection performed by the auditory system rely on the dynamics of a system of hair cells. In the inner ear, these acoustic receptors are primarily attached to an overlying structure which provides mechanical coupling between the hair bundles. While the dynamics of individual hair bundles have been extensively investigated, the influence of mechanical coupling on the motility of the system of bundles remains underdetermined. We developed a technique of mechanically coupling two active hair bundles, enabling us to probe the dynamics of the coupled system experimentally. We demonstrated that the coupling could enhance the coherence of hair bundles' spontaneous oscillation as well as their phase-locked response to sinusoidal stimuli, at the calcium concentration in the surrounding fluid near the physiological level. The empirical data were consistent with numerical results from a model of two coupled nonisochronous oscillators, each displaying a supercritical Hopf bifurcation. The model revealed that weak coupling can poise the system of unstable oscillators closer to the bifurcation by a shift in the critical point. In addition, the dynamics of strongly coupled oscillators far from criticality suggested that individual hair bundles may be regarded as nonisochronous oscillators. An optimal degree of nonisochronicity was required for the observed tuning behavior in the coherence of autonomous motion of the coupled system.

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A Bundle of Mechanisms: Inner-Ear Hair-Cell Mechanotransduction

Maoiléidigh

Ricci

2019

Trends in Neurosciences

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Mechanical Amplification Exhibited by Quiescent Saccular Hair Bundles

Cited by 4 publications

References 31 publications

Dynamics of Mechanically Coupled Hair-Cell Bundles of the Inner Ear

Dynamics of Mechanically Coupled Hair-Cell Bundles of the Inner Ear

Dynamics of mechanically coupled hair-cell bundles of the inner ear

A Bundle of Mechanisms: Inner-Ear Hair-Cell Mechanotransduction

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