Deep mining has started in the Huaibei mining area, and the serious threat of high confined water on the floor to the coal seam is gradually increasing. Based on the deep confined water mining project at working face II633 of the Hengyuan coal mine, this paper theoretically analyzes the damage depth of the floor and the risk of water inrush from the floor. The best proportion of grouting materials was quantitatively optimized by indoor experiments, and an industrial field test was conducted to judge the grouting effect. The results show that the failure depth of the bottom plate calculated by theoretical analysis is 31.73 m; a single factor test and a response surface optimization design method determined the best value of each index: water cement ratio 0.8, bentonite 2%, water reducer 0.6%, sodium silicate 2%. The damage depth of the bottom plate after grouting is 18.83~20 m, according to the field monitoring by the strain method. The optimized slurry significantly reduces the damage depth of the floor, ensures the safe and efficient mining of the coal seam above the high–pressure water, and has a high reference value for the safe mining of the coal seam under similar geological conditions.