Mechanical and Bioactivity Properties of Nano Ceramic Composite-Based Oxyapatite Materials

Beherei, Hanan H.; Mohamed, Khaled R.; El‐Bassyouni, Gehan T.

doi:10.1007/bf03401090

Cited by 3 publications

(3 citation statements)

References 44 publications

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“…A single drop of the prepared suspension was drop-casted onto a carbon-coated copper grid, air dried at room temperature for 40 minutes, before being microscopically analyzed. 18 To study the crystal morphology, microstructure details and elemental analysis of the prepared nano powder, scanning electron microscopy (SEM) model FEI, QUANTA, FEG, 250 equipped with energy dispersive X-ray analysis unit (EDX) was used. Samples were sputter coated with a thin film of gold to ensure a high quality image.…”

Section: Methodsmentioning

confidence: 99%

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Biological and Mechanical Properties of Denture Base Material as a Vehicle for Novel Hydroxyapatite Nanoparticles Loaded with Drug

et al. 2020

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Purpose: This study aimed to evaluate the biological and mechanical properties of the poly(methyl methacrylate) (PMMA) denture base material as a vehicle incorporating novel hydroxyapatite nanoparticles (HA-NP) loaded with metronidazole (MZ) drug. Methods: HA-NP was prepared via wet-chemical-method, characterized by XRD, SEM/EDX, TEM, Fourier-transform infrared spectroscopy (FTIR), as well as the measurement of surface area and pore-size distribution. Four drug delivery formulas were prepared in the form of discs (10 x 2 mm) as follows: F1 (MZ/ HA-NP/PMMA), F2 (HA-NP/ PMMA), F3 (control-PMMA) and F4 (MZ/PMMA). Characterization of all formulas was performed using differential scanning calorimetry (DSC) and FTIR. MZ release rate, antimicrobial properties against three oral pathogens, cytotoxicity (MTT assay) and surface micro-hardness were also assessed. Statistical analysis of data was performed using one-way ANOVA test (P < 0.05). Results: DSC thermograms showed compatibility among MZ, HA-NP and PMMA along with physical stability over 6 months storage period at room temperature. FTIR spectroscopy proved the absence of any possible chemical interaction with MZ. MZ-HA-NP/PMMA formula showed relatively better drug release compared to MZ-PMMA. Both formulas showed statistically significant antimicrobial potentials against two microbial strains. MTT demonstrated reduction in cell cytotoxicity after 96 hours with the least value for HA-NP. Surface micro-hardness revealed non-significant reduction compared with the control PMMA. Conclusion: A novel biocompatible drug nanocarrier (HA-NP) was developed and incorporated in PMMA denture base material as a vehicle to allow prolonged sustained drug release to manage oral infections.

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Section: Methodsmentioning

confidence: 99%

“…A single drop of the prepared suspension was drop-casted onto a carbon-coated copper grid, air dried at room temperature for 40 minutes, before being microscopically analyzed. 18 …”

Section: Methodsmentioning

confidence: 99%

Biological and Mechanical Properties of Denture Base Material as a Vehicle for Novel Hydroxyapatite Nanoparticles Loaded with Drug

et al. 2020

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“…Shells rich in calcium sources proposed a choice of providing a low-cost raw material for the production of useful and environmental friending material such as hydroxyapatite (HA) [3]. HA is the hydroxyl endmember of the complex apatite group [4]. It is an inorganic synthetic biomaterial that added a special consideration as it has outstanding physico-chemical, structural, and mechanical properties [5].…”

Section: Introductionmentioning

confidence: 99%

Some optical and microstructure characteristics of effective cost ZnO-containing hydroxyapatite

Mahdy¹,

Sherif²,

Kenawy³

et al. 2022

Phys. Scr.

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Metal oxide like zinc oxide (ZnO) is recognized to be one of the versatile inorganic compounds due to its physical properties. Crystalline compositions, morphology, particle size, and chemical bonds of pure hydroxyapatite (HA) and ZnO/HA were characterized by X-ray diffraction (XRD), Scanning and transmission electron microscopy (SEM and TEM), Fourier transform infrared spectroscopy (FT-IR), and Raman scattering detected crystalline and bond structure. Nanocomposites were crystallized in a main monoclinic phase of HA and a minor hexagonal phase of ZnO with particle size (18-29 nm) and grain size (75-200 nm) for the synthesized samples were identified. Moreover, the existence of the phosphate, carbonate ions, and hydroxyl groups in the HA and its composites structure was assured by the FT-IR assessment. The optical bandgap (Eg) of HA showed two transitions at 3.24 and 4.37 eV; these values decreased with the incorporation of ZnO. The determining optical and photoluminescence properties confirmed the presence of ZnO content in the HA matrix.

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Bioactivity and cell viability of Ag+- and Zr4+-co-doped biphasic calcium phosphate

et al. 2021

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Mechanical and Bioactivity Properties of Nano Ceramic Composite-Based Oxyapatite Materials

Cited by 3 publications

References 44 publications

Biological and Mechanical Properties of Denture Base Material as a Vehicle for Novel Hydroxyapatite Nanoparticles Loaded with Drug

Biological and Mechanical Properties of Denture Base Material as a Vehicle for Novel Hydroxyapatite Nanoparticles Loaded with Drug

Some optical and microstructure characteristics of effective cost ZnO-containing hydroxyapatite

Bioactivity and cell viability of Ag+- and Zr4+-co-doped biphasic calcium phosphate

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