Mechanical and biological properties of the micro-/nano-grain functionally graded hydroxyapatite bioceramics for bone tissue engineering

Zhou, Changchun; Deng, Congying; Chen, Xuening; Zhao, Xiaofeng; Chen, Ying; Fan, Yujiang; Zhang, Xingdong

doi:10.1016/j.jmbbm.2015.04.002

Cited by 72 publications

(30 citation statements)

References 58 publications

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“…In particular, the nanostructured hydroxyapatite (nano-HA) and nanoCaP nanomaterials have received considerable attention in the past decade [116,117]. The nano-HA has shown excellent biological performances compared to conventional HA [118,119,120,121]. Furthermore, nano-HA showed biocompatibility and bioactivity in respect of bone components, probably as a result of its similarity with the chemical component and mineral structure of bone tissue [97].…”

Section: Nanostructured Materials In Use For Tissue Engineering Inmentioning

confidence: 99%

Nanomaterials for Tissue Engineering In Dentistry

et al. 2016

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The tissue engineering (TE) of dental oral tissue is facing significant changes in clinical treatments in dentistry. TE is based on a stem cell, signaling molecule, and scaffold triad that must be known and calibrated with attention to specific sectors in dentistry. This review article shows a summary of micro- and nanomorphological characteristics of dental tissues, of stem cells available in the oral region, of signaling molecules usable in TE, and of scaffolds available to guide partial or total reconstruction of hard, soft, periodontal, and bone tissues. Some scaffoldless techniques used in TE are also presented. Then actual and future roles of nanotechnologies about TE in dentistry are presented.

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Section: Nanostructured Materials In Use For Tissue Engineering Inmentioning

confidence: 99%

Nanomaterials for Tissue Engineering In Dentistry

et al. 2016

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“…The apatite is the inorganic phase in the bone matrix, configuring and providing natural bone with its mechanical properties. This bone apatite is predominantly composed of HA, (Huang et al, ; Zhou et al, ) yet its raw material comes from amorphous calcium phosphate (ACP) (Boonrungsiman et al, ; Liu et al, ), considered a more stable precursor of carbonated HA, which is the main mineral phase of mineralized tissues, found in the sites during initial mineral deposition of bone and dental tissues (Beniash, Metzler, Lam, & Gilbert, ; Mahamid, Sharir, Addadi, & Weiner, ).…”

Section: Introductionmentioning

confidence: 99%

Amorphous calcium phosphate (ACP) in tissue repair process

Allegrini

Silva

Tsujita

et al. 2018

Microscopy Res & Technique

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Synthetic biomaterials submitted to new structural technologies have become ideal for the recovery of traumatized bone tissues and some bone substitutes such as bioactive glass, β-Tricalcium phosphate (β-TCP) and amorphous calcium phosphate (ACP) are being used in areas of tissue defects. For this study, ACP was produced in the form of fibers and then submitted to cytotoxicity testing. A sample of ACP was inserted into the mandibular region of a patient with a lost implant so after removal and curettage, the remaining bone site was filled with the ACP biomaterial. Preliminary cytotoxicity test was negative. After 15 weeks of healing, a titanium implant was inserted at the site. Clinical and radiographic follow-up was conducted for 12 months and sequential radiographic analyses revealed tissue formation resembling spongy bone. Images under immunohistochemistry demonstrated efficient deposition and osteoconduction of the newly deposited tissue. Residual portion of the CaO:P O outer layers served as a substrate for osteoid matrix deposition, aiding growth, and the results of fiber absorption favored maturation of the new bone tissue.

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“…Functionally Graded Ceramics (FGCs) are designed to withstand a variety of severe operative conditions, including high temperatures, corrosive environments, abrasion, mechanical, and thermal‐induced stresses . An overview of the FGC structures already developed and their main application fields is proposed in Table .…”

Section: Introduction To Fgmsmentioning

confidence: 99%

Functionally graded ceramics for biomedical application: Concept, manufacturing, and properties

Petit

Montanaro

Palmero

2018

Int J Applied Ceramic Tech

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Functionally Graded Materials (FGMs) represent a novel approach for the realization of innovative properties and/or functions that conventional homogeneous materials cannot accomplish. In conventional materials, in fact, the composition or the structure is uniform over the volume; on the opposite, in FGMs such features gradually change from layer to layer, with the aim of realizing a gradation of properties over the volume and performing a set of specified functions. Among FGMs, special attention is given today to Functionally Graded Ceramics (FGCs), designed and developed to withstand a variety of severe operative conditions, including high temperatures, corrosive environments, abrasion, mechanical, and thermal induced stresses. An important application field of FGCs is for medical prosthetic devices and artificial tissues, taking inspiration from the several examples of living tissues with graded structures. After an introduction on the rationale for using FGCs in the biomedical field, the 3 main types of graded materials developed today (eg, composition, porosity and microstructural graded ceramics) are here reviewed, highlighting the most innovative technologies used to develop them, their potentials and challenging features in comparison with the monolithic counterparts. K E Y W O R D S

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Mechanical and biological properties of the micro-/nano-grain functionally graded hydroxyapatite bioceramics for bone tissue engineering

Cited by 72 publications

References 58 publications

Nanomaterials for Tissue Engineering In Dentistry

Nanomaterials for Tissue Engineering In Dentistry

Amorphous calcium phosphate (ACP) in tissue repair process

Functionally graded ceramics for biomedical application: Concept, manufacturing, and properties

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