Limited investigations have evaluated the potential of using layered sections of normal-weight and lightweight concrete (NWC and LWC) mixtures in structural beams and slabs. The main objective of this paper is to assess the flexural strength properties of layered reinforced concrete (RC) beams, which help conserve natural resources and reduce construction weight. Six RC beams cast with different NWC/LWC combinations are tested to determine the damage patterns, concrete strains, ultimate load, displacements at failure, and ductility. The test results showed that the LWC cast in the tension zone (and up to the neutral axis) has a negligible effect on the beam’s stiffness and ultimate load since the overall behavior remains governed by the yielding of tensile steel reinforcement. Nevertheless, the deflection at failure and ductility seem to gradually curtail when the NWC is partially replaced by LWC at different elevations across the beam’s cross-section. A finite element analysis using ABAQUS software 6.14 is performed, and the results are compared with experimental data for model validation. Such data can be of interest to structural engineers and consultants aiming for optimized design of slabs and beams using layered concrete casting, which helps reduce the overall construction weight while maintaining the structural integrity of members.