Mechanical and Electrical Interaction of Biological Membranes with Nanoparticles and Nanostructured Surfaces

Abstract

In this review paper, we theoretically explain the origin of electrostatic interactions between lipid bilayers and charged solid surfaces using a statistical mechanics approach, where the orientational degree of freedom of lipid head groups and the orientational ordering of the water dipoles are considered. Within the modified Langevin Poisson–Boltzmann model of an electric double layer, we derived an analytical expression for the osmotic pressure between the planar zwitterionic lipid bilayer and charged solid planar surface. We also show that the electrostatic interaction between the zwitterionic lipid head groups of the proximal leaflet and the negatively charged solid surface is accompanied with a more perpendicular average orientation of the lipid head-groups. We further highlight the important role of the surfaces’ nanostructured topography in their interactions with biological material. As an example of nanostructured surfaces, we describe the synthesis of TiO2 nanotubular and octahedral surfaces by using the electrochemical anodization method and hydrothermal method, respectively. The physical and chemical properties of these nanostructured surfaces are described in order to elucidate the influence of the surface topography and other physical properties on the behavior of human cells adhered to TiO2 nanostructured surfaces. In the last part of the paper, we theoretically explain the interplay of elastic and adhesive contributions to the adsorption of lipid vesicles on the solid surfaces. We show the numerically predicted shapes of adhered lipid vesicles corresponding to the minimum of the membrane free energy to describe the influence of the vesicle size, bending modulus, and adhesion strength on the adhesion of lipid vesicles on solid charged surfaces.

Luminescence-enhanced conjugated polymer dots through thermal treatment for cell imaging

“…It may be speculated that water ionization intensifies at high temperature, which weakens the electric double layer of Pdots, and then weakens the repulsion of Pdots, and nano-sized agglomeration occurs. 46–49…”

“…It may be speculated that water ionization intensifies at high temperature, which weakens the electric double layer of Pdots, and then weakens the repulsion of Pdots, and nano-sized agglomeration occurs. [46][47][48][49] The morphology of Pdots was also studied by transmission electron microscopy (TEM). The typical TEM images of PFO-Pdots are shown in Fig.…”

Dielectric Study of Induced Phase Transitions in Lyotropic Liquid Crystals

“…Further analysis of the ordering parameter based on computer simulations and in-depth theoret-ical description will allow to link the symmetry of the system with molecular dynamics. This type of research is a valuable contribution to the creation of a modern model of the biological membrane, considering its interactions with nanoparticles or mi-croorganisms (Raval et al, 2021).…”

Investigation of Shape Transformations of Vesicles, Induced by Their Adhesion to Flat Substrates Characterized by Different Adhesion Strength

“…Thus, it is important to be able to model the shape transformation at the level of a single cell to understand the behavior of large adhering collections of cells. The results of our mathematical modeling of adhesion may be useful in explanation of the behavior of cells cultures confined and grown on a flat substrate [23], as well as in biomedical applications such as protection of the adhesion of platelets to vascular stents [24,25].…”