Mechanical and geometric property characterization of dry-coated tablets with contact ultrasonic techniques

Liu, Jingfei; Cetinkaya, Çetin

doi:10.1016/j.ijpharm.2010.03.060

Cited by 21 publications

(12 citation statements)

References 10 publications

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“…the accurate estimation of the effective values of the strain and hence, the Young's modulus. Several methodologies including ultrasonic techniques have been used to obtain the effective elastic moduli of pharmaceutical tablets (Akseli and Cetinkaya, 2008;Akseli et al, 2010;Bassam et al, 1990;Hancock, 2000;Ketolainen et al, 1995;Liu and Cetinkaya, 2010;Liu et al, 2011;Porion et al, 2010;Roberts et al, 1991). Since the Young's modulus has an explicit dependence on the porosity, Mazel et al, 2012, andPalomäki et al, 2015, have devised an experimental technique to measure the porosity dependent Young's modulus of pharmaceutical compacts.…”

Section: Link To Mechanical Propertiesmentioning

confidence: 99%

Characterisation of pore structures of pharmaceutical tablets: A review

Markl

Strobel

Schlossnikl

et al. 2018

International Journal of Pharmaceutics

107

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Traditionally, the development of a new solid dosage form is formulation-driven and less focus is put on the design of a specific microstructure for the drug delivery system. However, the compaction process particularly impacts the microstructure, or more precisely, the pore architecture in a pharmaceutical tablet. Besides the formulation, the pore structure is a major contributor to the overall performance of oral solid dosage forms as it directly affects the liquid uptake rate, which is the very first step of the dissolution process. In future, additive manufacturing is a potential game changer to design the inner structures and realise a tailor-made pore structure. In pharmaceutical development the pore structure is most commonly only described by the total porosity of the tablet matrix. Yet it is of great importance to consider other parameters to fully resolve the interplay between microstructure and dosage form performance. Specifically, tortuosity, connectivity, as well as pore shape, size and orientation all impact the flow paths and play an important role in describing the fluid flow in a pharmaceutical tablet. This review presents the key properties of the pore structures in solid dosage forms and it discusses how to measure these properties. In particular, the principles, advantages and limitations of helium pycnometry, mercury porosimetry, terahertz time-domain spectroscopy, nuclear magnetic resonance and X-ray computed microtomography are discussed.

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Section: Link To Mechanical Propertiesmentioning

confidence: 99%

Characterisation of pore structures of pharmaceutical tablets: A review

Markl

Strobel

Schlossnikl

et al. 2018

International Journal of Pharmaceutics

107

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“…In the current study, the outer tablet (coat) is composed of three structural components, namely the top outer layer, the bottom outer layer and the side outer layer. As reported in Liu and Cetinkaya (2010), the mechanical properties of the top and side layers could be substantially different even though they are made of the same powder. As indicated in Fig.…”

Section: Experimental Set-up and Materialsmentioning

confidence: 86%

“…2. Typical geometric and mechanical properties of the sample tablets are given as follows (Liu and Cetinkaya, 2010: the tablet mass density range is 1100-1150 kg/m 3 , the thicknesses of the top and bottom coat layers are 1.2 mm and 1.6 mm, respectively, due to the known core eccentricity in the tablet, the average mass density of the top layer is 1144.9 kg/m 3 , the travel times of pressure waves in the top and bottom layers are 1.05 s and 1.40 s respectively, the tablet diameter is 9.6 mm, the tablet thickness is 5.2 mm, the core diameter is 6.7 mm, and the core thickness is 2.4 mm. In each experiment, a fresh sample tablet is used to eliminate the effect of tablet material degradation due to the penetration of the acoustic couplant gel into coat and/or core materials and the associated effect on TOF measurements.…”

Section: Experimental Set-up and Materialsmentioning

confidence: 99%

“…Mechanical and geometric property characterization of drycoated tablets with air-coupled and direct contact ultrasonic techniques is investigated in Akseli and Cetinkaya (2008) and Liu and Cetinkaya (2010) respectively, and it is concluded that the mechanical properties and thickness of the outer layer of dry-coated tablets can be obtained with the utilization of a nondestructive acoustic pulse-echo method. Considering the millisecond (ms) time-scale dwell time of a typical commercial compaction press (from ∼5 ms to 80+ ms) (Levin, 2002) and the micro-seconds of pulse duration and time-of-flight (TOF) of an acoustics pulse in typical tablets, the results reported in Akseli et al (2008a) and later Leskinen et al (2010) indicates that the ultrasonic approach has potential to be employed for real-time in-die online monitoring of the geometric and mechanical properties of drug tablets.…”

Section: Introductionmentioning

confidence: 99%

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Real-time in-die compaction monitoring of dry-coated tablets

Liu¹,

Stephens²,

Kowalczyk³

et al. 2011

International Journal of Pharmaceutics

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“…Previously a set of a non-invasive/non-destructive, wave propagation-based techniques for the characterization of tablet properties have been introduced and reported (I. Ilgaz Akseli et al, 2009;Liu and Cetinkaya, 2010;Varghese and Cetinkaya, 2007;Smith et al, 2011;Vahdat et al, 2013). Current approach is based on the principle that the velocities of pressure (longitudinal) and shear (transverse) waves propagating in a medium depend on its elasticity (stiffness, hardness), and inertia (mass density and its spatial distribution) as well as its micro-granular structure.…”

Section: Introductionmentioning

confidence: 99%

Early detection of capping risk in pharmaceutical compacts

Vallabh

Hoag

et al. 2018

International Journal of Pharmaceutics

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Capping is a common mechanical defect in tablet manufacturing, exhibited during or after the compression process. Predicting tablet capping in terms of process variables (e.g. compaction pressure and speed) and formulation properties is essential in pharmaceutical industry. In current work, a nondestructive contact ultrasonic approach for detecting capping risk in the pharmaceutical compacts prepared under various compression forces and speeds is presented. It is shown that the extracted mechanical properties can be used as early indicators for invisible capping (prior to visible damage). Based on the analysis of X-ray cross-section images and a large set of waveform data, it is demonstrated that the mechanical properties and acoustic wave propagation characteristics is significantly modulated by the tablet's internal cracks and capping at higher compaction speeds and pressures. In addition, the experimentally extracted properties were correlated to the directly-measured porosity and tensile strength of compacts of Pearlitol®, Anhydrous Mannitol and LubriTose® Mannitol, produced at two compaction speeds and at three pressure levels. The effect compaction speed and pressure on the porosity and tensile strength of the resulting compacts is quantified, and related to the compact acoustic characteristics and mechanical properties. The detailed experimental approach and reported wave propagation data could find key applications in determining the bounds of manufacturing design spaces in the development phase, predicting capping during (continuous) tablet manufacturing, as well as online monitoring of tablet mechanical integrity and reducing batch-to-batch end-product quality variations. Disciplines Disciplines Pharmacy and Pharmaceutical Sciences Comments Comments

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Mechanical and geometric property characterization of dry-coated tablets with contact ultrasonic techniques

Cited by 21 publications

References 10 publications

Characterisation of pore structures of pharmaceutical tablets: A review

Characterisation of pore structures of pharmaceutical tablets: A review

Real-time in-die compaction monitoring of dry-coated tablets

Early detection of capping risk in pharmaceutical compacts

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