Mechanical and matrix effects of short and long-duration exposure to beta-aminopropionitrile in elastase-induced model abdominal aortic aneurysm in mice

Vascular Ultrasound for In Vivo Assessment of Arterial Pathologies in a Murine Model of Atherosclerosis and Aortic Aneurysm

“…Hemodynamic characteristics and changes in wall stress or morphology of the aneurysmal aorta might differ in those diseases from the ApoE −/− Ang II mouse model utilized, in which AAA is induced by increased blood pressure levels, hyperlipidemia, and atherosclerotic predisposition. Likewise, changes in collagen content and aortic stiffness might be altered in enzymatically induced AAA models and also in other models of atherosclerosis [26]. Finally, findings from animal models regarding hemodynamics and morphologic characteristics of the diseased aorta cannot be fully extrapolated to the conditions in humans, and the study is restricted due to the limited sample size, requiring further investigation.…”

Abdominal aortic aneurysms: insights into mechanical and extracellular matrix effects from mouse models

“…In this issue, Gueldner et al 9 reported on the mechanical and matrix effects using the periadventitial elastase mouse model with different durations of BAPN administration. They performed mechanical testing of fresh aortic sections to determine the tangent modulus (representing the aortic stiffness) and ultimate tensile strength (UTS; representing the maximal elasticity).…”

“…In conclusion, the study by Gueldner et al 9 determined temporal alterations of biomechanical properties and matrix profiles during AAA formation using periadventitial elastase application with the BAPN administration mouse model, providing important insights into the pathologic and mechanistic complexity of human AAAs.…”