This study examined the applicability of the equivalent core concept, which replaces a discrete core with a homogenized solid core representing its elastic properties, on a large-scale structure. To this end, numerical verifications were performed for corrugated core structures at two levels, the specimen level and structural level. Before the verifications, analytical equations were gathered from previous reports to obtain the homogenized elastic properties of corrugated cores. At the specimen-level verifications, the maximum deflections of the corrugated core panel specimens subject to three-point bending were calculated with sandwich beam theory, finite element models with discretely modeled cores and equivalent cores. For the structural-level verifications, the maximum deflection and natural frequency were computed from a discrete finite element model and an equivalent model of a railway car body structure. The results revealed that the equivalent models gave excellent agreement with the theoretical values if the same underlying boundary conditions were used; however, greater discrepancies were observed with the discrete models. In addition, for the structural-level verifications the equivalent core model reasonably approximated the discrete model with marginal accuracy. Therefore, employing the equivalent core concept can be expected to save computational costs in the initial design stage of large-scale structures.