Mechanical behavior and in vivo properties of newly designed bare metal stent for enhanced flexibility

Bae, In-Ho; Lim, Kyung-Seob; Park, Jun-Kyu; Park, Dae-Sung; Lee, So‐Youn; Jang, Eun-Jae; Ji, Mi; Sim, Doo Sun; Hong, Young Joon; Ahn, Youngkeun; Park, Jong Chun; Kang, Jung Chaee; Kim, In-Su; Nah, Jae‐Woon; Cho, Jeong Gwan

doi:10.1016/j.jiec.2014.05.045

Cited by 46 publications

(26 citation statements)

References 37 publications

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“…In this study, cobalt–chromium (Co–Cr, 3.0 × 18.0 mm, L605) alloy was used as a stent material because many researchers have reported that this alloy is the most biocompatible material for coronary stents . Stents were manufactured by Chonnam National University Hospital (CNUH) . Fabrication of the bare metal stents (BMS) with the Co–Cr alloy was performed using a laser cutter (Rofin, Starcut, Hamburg, Germany).…”

Section: Methodsmentioning

confidence: 99%

Bilirubin coating attenuates the inflammatory response to everolimus‐coated stents

et al. 2017

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The aim of this study was to evaluate the effects of bilirubin- and/or everolimus (EVL)-coated stents to prevent arterial neointimal hyperplasia and inflammation in vitro and in vivo. The stents were prepared by spray coating bare metal stents (BMS) with bilirubin and/or EVL. Study groups were divided into (1) BMS, (2) bilirubin-coated stents (BES), (3) commercialized stents (Synergy™; EES), and (4) bilirubin/EVL-coated stents (B-EES). The coating thickness and drug release rates were comparable to previous reports (i.e., <4 µm thickness and 50% drug release in 7 days). Smooth muscle cell migration was inhibited in both EVL-containing groups (20.5 ± 3.80% in EES and 18.4 ± 2.55% in B-EES) compared to the non-EVL-containing groups (78.0 ± 6.41% in BMS and 76.1 ± 4.88% in BES) (n = 10, p < 0.05). Stents were randomly implanted to 40 coronary arteries in 20 pigs and subjected to various analyses after 4 weeks of implantation. As results, the inflammation score was dramatically increased in the EES group (2.1 ± 0.42) compared to that of the other groups (1.5 ± 0.55, 1.3 ± 0.23, and 1.5 ± 0.27 for BMS, BES, and B-EES, respectively, n = 10, p < 0.05). Immunofluorescence analysis revealed that inflammation was prevented in the bilirubin-containing groups (BES and B-EES). However, the percent area of restenosis was decreased in the EVL-containing groups (20.5 ± 4.11% for EES and 18.4 ± 3.61% for B-EES) compared to the non-EVL-containing groups (32.3 ± 6.41% for BMS and 29.6 ± 5.95% for BES, n = 10, p < 0.05). The percent areas of restenosis determined by histopathology, optical coherence tomography, and micro-computed tomography were consistent. In addition, the stent was barely covered in the EES and B-EES groups at 4 weeks postimplantation. These dual drug-coated stents may be especially beneficial to patients who have an increased risk of inflammation. These stents have great potential for use in cardiovascular applications. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1486-1495, 2018.

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Section: Methodsmentioning

confidence: 99%

Bilirubin coating attenuates the inflammatory response to everolimus‐coated stents

et al. 2017

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“…In this study, the cobalt‐chromium (Co‐Cr, 3.0 × 13, 16, 18.0 mm, L605) alloy was used as the stent material because many researchers have reported that the Co‐Cr alloy is the most appropriate material in terms of biocompatible aspects . They were manufactured by Chonnam National University Hospital (CNUH) . Fabrication of the bare metal stent (BMS) with the Co‐Cr alloy was performed using a laser cutter (Rofin, Starcut, Hamburg, Germany).…”

Section: Methodsmentioning

confidence: 99%

“…22 They were manufactured by Chonnam National University Hospital (CNUH). 23 Fabrication of the bare metal stent (BMS) with the Co-Cr alloy was performed using a laser cutter (Rofin, Starcut, Hamburg, Germany). Thereafter, it was treated in an acidic atmosphere (50% H 2 SO 4 ) for 1 h to remove crush and burrs.…”

Section: Preparation Of Bare Metal Stentsmentioning

confidence: 99%

Comparison of dextran‐based sirolimus‐eluting stents and PLA‐based sirolimus‐eluting stents in vitro and in vivo

Lee

Bae

Park

et al. 2016

J Biomedical Materials Res

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The aim of this study was to compare dextran and Poly(l-lactide) (PLLA) polymer stent coatings as mediators for sirolimus (SRL) drug elution in a porcine coronary model. The bare metal stent (BMS) surface was first coated with a layer of SRL and then either dextran (DSS, a natural polymer) or PLA (PSS, a synthetic polymer). The release velocity of SRL was slightly faster in DSS than PSS over the first 7 days (78.5% and 62.3%, respectively, n = 10, p < 0.05) and continued to 28 days in both groups. The contact angle was dramatically decreased in DSS (38.7° ± 1.24) compared to BMS and PSS groups (72.7° ± 5.32 and 81.1º ± 1.70, respectively, n = 10, p < 0.05). Smooth muscle cell migration was arrested in both the DSS and PSS-treated groups compared to that in the nontreated group (4.2% ± 0.31, 5.8% ± 0.60, 80.0% ± 4.4, respectively, n = 10, p < 0.05). In the animal study, there were no significant differences in the injury score, the internal elastic lamina, and the lumen area among the groups. However, percent area stenosis was significantly decreased in the SRL-containing group (27.5% ± 2.52 in DSS and 27.9% ± 3.30 in PSS) compared to BMS (35.9% ± 3.51, p < 0.05). The fibrin score was higher in the PSS (2.9 ± 0.31) than BMS (2.1 ± 0.12) and DSS (2.5 ± 0.66). The inflammation score in the DSS (0.7 ± 0.21) was similar to that in the BMS (0.7 ± 0.12), which was dramatically lower than that PSS (1.5 ± 0.18, p < 0.005). Immunofluorescence analysis revealed that endothelialization was increased and inflammation prevented in the DSS. These results suggest that dextran may be useful for the fabrication of drug eluting stent as an alternative existing synthetic polymer. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 301-310, 2017.

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“…The BMS (CNUH stent) used in the study was fabricated by laser-cut processing in a cobalt chromium alloy tube (L605 Co-Cr alloy) and electropolished to a strut thickness of \70 lm [14,15]. An ultrasonic spray method was used to apply coatings to the prepared BMS (3 9 16 mm).…”

Section: Preparation Of Aes Ses and Sasmentioning

confidence: 99%

Effect of stents coated with a combination of sirolimus and alpha-lipoic acid in a porcine coronary restenosis model

Lim

Park

Jeong

et al. 2016

J Mater Sci: Mater Med

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The aim of this study was to evaluate antiproliferative sirolimus- and antioxidative alpha-lipoic acid (ALA)-eluting stents using biodegradable polymer [poly-L-lactic acid (PLA)] in a porcine coronary overstretch restenosis model. Forty coronary arteries of 20 pigs were randomized into four groups in which the coronary arteries had a bare metal stent (BMS, n = 10), ALA-eluting stent with PLA (AES, n = 10), sirolimus-eluting stent with PLA (SES, n = 10), or sirolimus- and ALA-eluting stent with PLA (SAS, n = 10). A histopathological analysis was performed 28 days after the stenting. The ALA and sirolimus released slowly over 30 days. There were no significant differences between groups in the injury or inflammation score; however, there were significant differences in the percent area of stenosis (56.2 ± 11.78% in BMS vs. 51.5 ± 12.20% in AES vs. 34.7 ± 7.23% in SES vs. 28.7 ± 7.30% in SAS, P < 0.0001) and fibrin score [1.0 (range 1.0-1.0) in BMS vs. 1.0 (range 1.0-1.0) in AES vs. 2.0 (range 2.0-2.0) in SES vs. 2.0 (range 2.0-2.0) in SAS, P < 0.0001] between the four groups. The percent area of stenosis based on micro-computed tomography corresponded with the restenosis rates based on histopathological stenosis in different proportions in the four groups (54.8 ± 7.88% in BMS vs. 50.4 ± 14.87% in AES vs. 34.5 ± 7.22% in SES vs. 28.9 ± 7.22% in SAS, P < 0.05). SAS showed a better neointimal inhibitory effect than BMS, AES, and SES at 1 month after stenting in a porcine coronary restenosis model. Therefore, SAS with PLA can be a useful drug combination for coronary stent coating to suppress neointimal hyperplasia.

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Mechanical behavior and in vivo properties of newly designed bare metal stent for enhanced flexibility

Cited by 46 publications

References 37 publications

Bilirubin coating attenuates the inflammatory response to everolimus‐coated stents

Bilirubin coating attenuates the inflammatory response to everolimus‐coated stents

Comparison of dextran‐based sirolimus‐eluting stents and PLA‐based sirolimus‐eluting stents in vitro and in vivo

Effect of stents coated with a combination of sirolimus and alpha-lipoic acid in a porcine coronary restenosis model

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