Mechanical behavior of cold‐water fish gelatin gels crosslinked with 1,4‐butanediol diglycidyl ether

Czerner, Marina; Prudente, Mariano; Martucci, Josefa Fabiana; Rueda, Federico; Fasce, Laura Alejandra

doi:10.1002/app.48985

Cited by 6 publications

(4 citation statements)

References 46 publications

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“…Collagen can be either processed by acidic or lime-curing treatment to obtain type A and type B gelatin, respectively. When crosslinked, gelatin forms hydrogels that gained success as scaffolds for regenerative medicine [2], wound dressings [3] and drug delivery applications [4], thanks to its availability, intrinsic presence of cell-adhesive motifs (i.e., RGD sequence), in vivo degradability, and versatility [5]. Different fabrication technologies can be selected to produce gelatin hydrogels (e.g., freeze-drying, particulate leaching, emulsion, 3D printing, electrospinning)…”

Section: Introductionmentioning

confidence: 99%

Characterization of gelatin hydrogels derived from different animal sources

et al. 2020

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Section: Introductionmentioning

confidence: 99%

Characterization of gelatin hydrogels derived from different animal sources

et al. 2020

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“…BDDGE is water-soluble and can be used as a bifunctional crosslinker to bind amino acids. It is widely used for the crosslinking of HA and gelatin [ 122 ]. Zeeman et al studied its mechanism by crosslinking sheep skin with BDDGE (Fig.…”

Section: Modificationsmentioning

confidence: 99%

Swim bladder-derived biomaterials: structures, compositions, properties, modifications, and biomedical applications

Lan,

Luo,

et al. 2024

J Nanobiotechnol

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Animal-derived biomaterials have been extensively employed in clinical practice owing to their compositional and structural similarities with those of human tissues and organs, exhibiting good mechanical properties and biocompatibility, and extensive sources. However, there is an associated risk of infection with pathogenic microorganisms after the implantation of tissues from pigs, cattle, and other mammals in humans. Therefore, researchers have begun to explore the development of non-mammalian regenerative biomaterials. Among these is the swim bladder, a fish-derived biomaterial that is rapidly used in various fields of biomedicine because of its high collagen, elastin, and polysaccharide content. However, relevant reviews on the biomedical applications of swim bladders as effective biomaterials are lacking. Therefore, based on our previous research and in-depth understanding of this field, this review describes the structures and compositions, properties, and modifications of the swim bladder, with their direct (including soft tissue repair, dural repair, cardiovascular repair, and edible and pharmaceutical fish maw) and indirect applications (including extracted collagen peptides with smaller molecular weights, and collagen or gelatin with higher molecular weights used for hydrogels, and biological adhesives or glues) in the field of biomedicine in recent years. This review provides insights into the use of swim bladders as source of biomaterial; hence, it can aid biomedicine scholars by providing directions for advancements in this field.

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“…In our previous works, we also found that the use of butanediol diglycidyl ether (BDDE) is safe, as the biocompatibility and cell viability did not change with the use of this material [19]. BDDE was also used to crosslink fish-derived gelatin, and the mechanical properties were examined but not as a biologically applicable material [20]. It had also been discovered earlier that BDDE is suitable to crosslink primary amino groups, and it has been used to modify collagen from sheep [21].…”

Section: Introductionmentioning

confidence: 99%

Water-Insoluble, Thermostable, Crosslinked Gelatin Matrix for Soft Tissue Implant Development

Varga,

Smeller,

Várdai

et al. 2024

IJMS

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In this present study, the material science background of crosslinked gelatin (GEL) was investigated. The aim was to assess the optimal reaction parameters for the production of a water-insoluble crosslinked gelatin matrix suitable for heat sterilization. Matrices were subjected to enzymatic degradation assessments, and their ability to withstand heat sterilization was evaluated. The impact of different crosslinkers on matrix properties was analyzed. It was found that matrices crosslinked with butanediol diglycidyl ether (BDDE) and poly(ethylene glycol) diglycidyl ether (PEGDE) were resistant to enzymatic degradation and heat sterilization. Additionally, at 1 v/v % crosslinker concentration, the crosslinked weight was lower than the starting weight, suggesting simultaneous degradation and crosslinking. The crosslinked weight and swelling ratio were optimal in the case of the matrices that were crosslinked with 3% and 5% v/v BDDE and PEGDE. FTIR analysis confirmed crosslinking, and the reduction of free primary amino groups indicated effective crosslinking even at a 1% v/v crosslinker concentration. Moreover, stress–strain and compression characteristics of the 5% v/v BDDE crosslinked matrix were comparable to native gelatin. Based on material science measurements, the crosslinked matrices may be promising candidates for scaffold development, including properties such as resistance to enzymatic degradation and heat sterilization.

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Mechanical behavior of cold‐water fish gelatin gels crosslinked with 1,4‐butanediol diglycidyl ether

Cited by 6 publications

References 46 publications

Characterization of gelatin hydrogels derived from different animal sources

Characterization of gelatin hydrogels derived from different animal sources

Swim bladder-derived biomaterials: structures, compositions, properties, modifications, and biomedical applications

Water-Insoluble, Thermostable, Crosslinked Gelatin Matrix for Soft Tissue Implant Development

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