Mechanical behavior of damaged trabecular bone

Keaveny, Tony M.; Wachtel, Edward F.; Guo, X. Edward; Hayes, Wilson C.

doi:10.1016/0021-9290(94)90040-x

Cited by 104 publications

(99 citation statements)

References 33 publications

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“…Following vertebral compressive fracture, there is a substantial reduction in mechanical strength and stiffness [2,3,4,13,24,25,33]. In this study, a microstructural FE model and microdamage scheme [19,22] were used to simulate the effects of parapedicular vertebroplasty on thoracic vertebral body mechanical properties.…”

Section: Discussionmentioning

confidence: 99%

Damage-based finite-element vertebroplasty simulations

Kosmopoulos

Keller

2004

Eur Spine J

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Section: Discussionmentioning

confidence: 99%

Damage-based finite-element vertebroplasty simulations

Kosmopoulos

Keller

2004

Eur Spine J

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“…During that phase, the aggregated particles were probably becoming more damaged. Structurally damaged cancellous bone is known to have a much lower elastic modulus (Keaveny et al 1994). However, on impacting the graft layer, such damage would be compensated by the ongoing slow rise in compactness of the morselized grafts.…”

Section: Discussionmentioning

confidence: 99%

Stiffness and compactness of morselized grafts during impaction: An in vitro study with human femoral heads

Bavadekar

Cornu

Godts

et al. 2001

Acta Orthopaedica Scandinavica

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“…The specimens were loaded in compression three times from 0 to 0.4% strain at a rate of 0.5% per second, and the apparent Young's modulus was calculated from a second order polynomial fit to the stress strain data over a strain range from 0 to 0.2% (Morgan, et al, 2001). Next, damage was induced by overloading the specimens in compression to 3% strain at 0.5% strain per second, which has been shown to induce microdamage in trabecular bone (Arthur Moore and Gibson, 2002;Keaveny, et al, 1994;Wang, X and Niebur, 2006). The damaged Young's modulus was subsequently measured with three additional non-destructive loading cycles.…”

Section: Methodsmentioning

confidence: 99%

Detection of trabecular bone microdamage by micro-computed tomography

Wang

Masse

Leng

et al. 2007

Journal of Biomechanics

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Microdamage is an important component of bone quality and affects bone remodeling. Improved techniques to assess microdamage without the need for histological sectioning would provide insight into the role of microdamage in trabecular bone strength by allowing the spatial distribution of damage within the trabecular microstructure to be measured. Nineteen cylindrical trabecular bone specimens were prepared and assigned to two groups. The specimens in group I were damaged to 3% compressive strain and labeled with BaSO 4 . Group II was not loaded, but was labeled with BaSO 4 . Micro-CT images of the specimens were obtained at 10 μm resolution. The median intensity of the treated bone tissue was compared between groups. Thresholding was also used to measure the damaged area fraction in the micro-CT scans. The histologically measured damaged area fraction, the median CT intensity, and the micro-CT measured damaged area fraction were all higher in the loaded group than in the unloaded group, indicating that the micro-CT images could differentiate the damaged specimen group from the unloaded specimens. The histologically measured damaged area fraction was positively correlated with the micro-CT measured damaged area fraction and with the median CT intensity of the bone, indicating that the micro-CT images can detect microdamage in trabecular bone with sufficient accuracy to differentiate damage levels between samples. This technique provides a means to non-invasively assess the three-dimensional distribution of microdamage within trabecular bone test specimens, and could be used to gain insight into the role of trabecular architecture in microdamage formation.

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Mechanical behavior of damaged trabecular bone

Cited by 104 publications

References 33 publications

Damage-based finite-element vertebroplasty simulations

Damage-based finite-element vertebroplasty simulations

Stiffness and compactness of morselized grafts during impaction: An in vitro study with human femoral heads

Detection of trabecular bone microdamage by micro-computed tomography

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