Mechanical behavior of human aortas: Experiments, material constants and 3-D finite element modeling including residual stress

Labrosse, Michel R.; Beller, Carsten J.; Mesana, Thierry G.; Veinot, John P.

doi:10.1016/j.jbiomech.2009.02.009

Cited by 72 publications

(57 citation statements)

References 22 publications

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“…Interestingly, the model as mounted on the ViVitro system also allowed for an axial elongation of the aortic root by 15% of the sino-tubular junction diameter. Such elongation has already been reported in vivo by Beller et al [10] and Labrosse et al [11]. Figure 2(b) shows the pressure waveforms obtained after TAV implantation.…”

Section: Resultssupporting

confidence: 81%

An In Vitro Model of Aortic Stenosis for the Assessment of Transcatheter Aortic Valve Implantation

Maleki

Shahriari

Labrosse

et al. 2014

Journal of Biomechanical Engineering

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A significant number of elderly patients with severe symptomatic aortic stenosis are denied surgical aortic valve replacement (SAVR) because of high operative risk. Transcatheter aortic valve implantation (TAVI) has emerged as a valid alternative to SAVR in these patients. One of the main characteristics of TAVI, when compared to SAVR, is that the diseased native aortic valve remains in place. For hemodynamic testing of new percutaneous valves and clinical training, one should rely on animal models. However, the development of an appropriate animal model of severe aortic stenosis is not straightforward. This work aims at developing and testing an elastic model of the ascending aorta including a severe aortic stenosis. The physical model was built based on a previous silicone model and tested experimentally in this study. Experimental results showed that the error between the computer-aided design (CAD) file and the physical elastic model was <5%, the compliance of the ascending aorta was 1.15 ml/mm Hg, the effective orifice area (EOA) of the stenotic valve was 0.86 cm 2 , the peak jet velocity was 4.9 m/s and mean transvalvular pressure gradient was 50 mm Hg, consistent with as severe. An EDWARDS-SAPIEN 26 mm valve was then implanted in the model leading to a significant increase in EOA (2.22 cm 2 ) and a significant decrease in both peak jet velocity (1.29 m/s) and mean transvalvular pressure gradient (3.1 mm Hg). This model can be useful for preliminary in vitro testing of percutaneous valves before more extensive animal and in vivo tests.

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Section: Resultssupporting

confidence: 81%

An In Vitro Model of Aortic Stenosis for the Assessment of Transcatheter Aortic Valve Implantation

Maleki

Shahriari

Labrosse

et al. 2014

Journal of Biomechanical Engineering

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“…This limits the elastic response of the artery and yields a substantially stiffer vessel even at low inflation pressures. The median circumferential stretch of the normal aorta of 1.23 is similar to values reported by [18].…”

Section: Diameter Diametersupporting

confidence: 84%

Acoustic Radiation Force Impulse imaging for aneurysms

Tierney

Dumont

Callanan

et al. 2009

2009 IEEE International Ultrasonics Symposium

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Abstract-A method for reliable, noninvasive estimation of Abdominal Aortic Aneurysms (AAA) wall mechanics may be a useful clinical tool for rupture prediction. An in vitro AAA model was developed from an excised porcine aorta, with elastase treatment. The AAA model behaviour was analysed using Acoustic Radiation Force Impulse (ARFI) imaging techniques to generate displacements in both aneurysmal and normal aortic tissue. The incremental modulus of the arteries was indicative of early collagen recruitment, typical in aneurysms due to elastin degradation. Opening angle measurement showed a four fold decrease from healthy aorta to AAA model. The mechanical changes that occur during aneurysm formation were found to be detectable using ARFI imaging.An in vivo aorta was imaged to demonstrate the viability of excitation of abdominal aorta using ARFI imaging. B-mode and ARFI images were acquired for one diseased aorta in a female volunteer. Cardiac motion was minimized using ECG-triggered beam sequences, and ARFI images were acquired during diastole. Residual motion was treated with a linear motion filter. Diseased aortic images revealed greater displacement in the intraluminal thrombus than the wall of the aorta.

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“…By pre-stretching the arterial samples, we have attempted to properly account for the in vivo condition. For the specific choice of circumferential and axial tissue pre-stretch (22% and 12%, respectively) we were guided by the work of Learoyd & Taylor [43] and Labrosse et al [44]. The 22 per cent circumferential strain is not matched with a known transmural pressure.…”

Section: Statisticsmentioning

confidence: 99%

Determination of the layer-specific distributed collagen fibre orientations in human thoracic and abdominal aortas and common iliac arteries

Schriefl

Zeindlinger

Pierce

et al. 2011

J. R. Soc. Interface.

314

294

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The established method of polarized microscopy in combination with a universal stage is used to determine the layer-specific distributed collagen fibre orientations in 11 human non-atherosclerotic thoracic and abdominal aortas and common iliac arteries (63 + 15.3 years, mean + s.d.). A dispersion model is used to quantify over 37 000 recorded fibre angles from tissue samples. The study resulted in distinct fibre families, fibre directions, dispersion and thickness data for each layer and all vessels investigated. Two fibre families were present for the intima, media and adventitia in the aortas, with often a third and sometimes a fourth family in the intima in the respective axial and circumferential directions. In all aortas, the two families were almost symmetrically arranged with respect to the cylinder axis, closer to the axial direction in the adventitia, closer to the circumferential direction in the media and in between in the intima. The same trend was found for the intima and adventitia of the common iliac arteries; however, there was only one preferred fibre alignment present in the media. In all locations and layers, the observed fibre orientations were always in the tangential plane of the walls, with no radial components and very small dispersion through the wall thickness. A wider range of in-plane fibre orientations was present in the intima than in the media and adventitia. The mean total wall thickness for the aortas and the common iliac artery was 1.39 and 1.05 mm, respectively. For the aortas, a slight thickening of the intima and a thinning of the media in increasingly distal regions were observed. A clear intimal thickening was present distal to the branching of the celiac arteries. All data, except for the media of the common iliac arteries, showed two prominent collagen fibre families for all layers so that two-fibre family models seem most appropriate.

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Mechanical behavior of human aortas: Experiments, material constants and 3-D finite element modeling including residual stress

Cited by 72 publications

References 22 publications

An In Vitro Model of Aortic Stenosis for the Assessment of Transcatheter Aortic Valve Implantation

An In Vitro Model of Aortic Stenosis for the Assessment of Transcatheter Aortic Valve Implantation

Acoustic Radiation Force Impulse imaging for aneurysms

Determination of the layer-specific distributed collagen fibre orientations in human thoracic and abdominal aortas and common iliac arteries

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