Mechanical behaviour of alginate-gelatin hydrogels for 3D bioprinting

Giuseppe, Michael Di; Law, Nicholas; Webb, Braeden; Macrae, Ryley A.; Liew, Lawrence J.; Sercombe, T.B.; Dilley, Rodney J.; Doyle, Barry

doi:10.1016/j.jmbbm.2017.12.018

Cited by 313 publications

(253 citation statements)

References 24 publications

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“…One study showed that for a 7% alginate/8% gelatin hydrogel, optimum printing parameters at 37 • C are as follows: nozzle gauge = 30 G, printing pressure = 100 kPa, and printing speed = 4 mm/s (Webb and Doyle, 2017). Storage of alginate can be vast depending upon purpose; for example, cells encapsulated with alginate can be stored comfortably between 0 and 30 • C and are fit for purpose, whereas it has been shown that in an alginate/gelatin hydrogel, storage at 3 • C prolonged degradation when compared to storage at 37 • C (Giuseppe et al, 2018).…”

Section: Plant-derived Biomaterials Alginatementioning

confidence: 99%

Plant-Derived Biomaterials: A Review of 3D Bioprinting and Biomedical Applications

et al. 2019

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The pursuit of appropriate, biocompatible materials is one of the primary challenges in translational bioprinting. The requirement to refine a biomaterial into a bioink places additional demands on the criteria for candidate biomaterials. The material must enable extrusion as a liquid bioink and yet be capable of maintaining its shape in the post-printing phase to yield viable tissues, organs and biological materials. Plant-derived biomaterials show great promise in harnessing both the natural strength of plant microarchitecture combined with their natural biological roles as supporters of cell growth. The aim of this review article is to outline the most widely used biomaterials derived from land plants and marine algae: nanocellulose, pectin, starch, alginate, agarose, fucoidan, and carrageenan, with an in-depth focus on nanocellulose and alginate. The properties that render these materials as promising bioinks for three dimensional bioprinting is herein discussed alongside their potential in 3D bioprinting for tissue engineering, drug delivery, wound healing, and implantable medical devices.

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Section: Plant-derived Biomaterials Alginatementioning

confidence: 99%

Plant-Derived Biomaterials: A Review of 3D Bioprinting and Biomedical Applications

et al. 2019

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“…AM materials already demonstrate an inherent responsiveness to manufacturing parameters [23][24][25][26]. However, to date, the design of AM materials does not incorporate variable manufacturing parameters into design software.…”

Section: Human Development and Additive Manufacturingmentioning

confidence: 99%

Temporal design for additive manufacturing

Saliba

Kirkman-Brown

Thomas-Seale

2020

Int J Adv Manuf Technol

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Additive manufacturing (AM) is expected to generate huge economic revenue by 2025; however, this will only be realised by overcoming the barriers that are preventing its increased adoption to end-use parts. Design for AM (DfAM) is recognised as a multi-faceted problem, exasperated by constraints to creativity, knowledge propagation, insufficiencies in education and a fragmented software pipeline. This study proposes a novel approach to increase the creativity in DfAM. Through comparison between DfAM and in utero human development, the unutilised potential of design through the time domain was identified. Therefore, the aim of the research is to develop a computer-aided manufacturing (CAM) programme to demonstrate design through the time domain, known as Temporal DfAM (TDfAM). This was achieved through a bespoke MATLAB code which applies a linear function to a process parameter, discretised across the additive build. TDfAM was demonstrated through the variation of extrusion speed combined with the infill angle, through the axial and in-plane directions. It is widely accepted in the literature that AM processing parameters change the properties of AM materials. Thus, the application of the TDfAM approach offers the engineer increased creative scope and control, whilst inherently upskilling knowledge, in the design of AM materials.

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“…Printing heads were automatically meshed considering tetrahedral elements and two hydrogels (alginate and gelatine) commonly used for bioprinting applications (see Table 2 for material properties). Based on an extensive literature search the suitable printing concentrations were determined as 2-4% for sodium alginate and 8% for gelatine solutions [10,11]. For solutions containing 3% of alginate the extrusion velocity is assumed to be 50 mm/s, which allows viscous flows with Reynolds numbers ranging between 0.003 and 0.015, far below the turbulent flow transition boundary.…”

Section: Simulation Conditionsmentioning

confidence: 99%

A novel printing channel design for multi-material extrusion additive manufacturing

Urhal

2020

MATEC Web Conf.

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Additive manufacturing has a great potential in terms of its capability to produce components with complex geometries and to make multi-material and composite products by combining different materials in a single manufacturing platform. Current trends for the multi-material extrusion additive manufacturing process are categorized by multi-nozzle systems and multi-material inlet systems. In the case of multiple nozzle system, materials are deposited from different nozzles in sequence. On the other hand, in the case of multi-material inlet system, different materials are sent into a mixing tube and deposited as a mixture of materials. In this case, functionally graded parts can be fabricated by changing the volume fraction of two or more materials. Hence, the fabrication of parts with a continuous material supply by varying ratios for the extrusion technologies requires the development of printing heads with suitable printing channels, capable of varying the mixing ratio of different materials. To evaluate the effect of different printing channel designs on the material’s flow pattern and the functionally graded material printability, this paper presents a three-dimensional transient computational fluid dynamics (CFD) simulation of the two miscible liquid-liquid system in a printing channel. Different geometries and materials are considered

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Mechanical behaviour of alginate-gelatin hydrogels for 3D bioprinting

Cited by 313 publications

References 24 publications

Plant-Derived Biomaterials: A Review of 3D Bioprinting and Biomedical Applications

Plant-Derived Biomaterials: A Review of 3D Bioprinting and Biomedical Applications

Temporal design for additive manufacturing

A novel printing channel design for multi-material extrusion additive manufacturing

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