Mechanical Bowel Preparation for Elective Colorectal Surgery: A Prospective, Randomized, Surgeon-Blinded Trial Comparing Sodium Phosphate and Polyethylene Glycol-Based Oral Lavage Solutions

Oliveira, Lúcia Câmara Castro; Wexner, Steven D.; Daniel, Norma; DeMarta, D.; Weiss, Eric G.; Nogueras, Juan J.; Bernstein, M.

doi:10.1016/s0022-5347(01)62180-3

Cited by 46 publications

(57 citation statements)

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“…The sample size was calculated by using a reference rate of 87% for appropriately prepared bowel as reported by Oliveira et al [5] . The sample size of 110 participants was selected to detect 80% power at the 0.05 level and a difference of 20% in the outcome measurement.…”

Section: Methodsmentioning

confidence: 99%

Appropriate Bowel Preparation for Laparotomy Gynecologic Surgery: A Prospective, Surgeon-Blinded Randomized Study

Suadee

Suprasert²

2016

Gynecol Obstet Invest

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Objective: To compare the surgeon's satisfaction during gynecological laparotomy surgery and patient's satisfaction as well as quality of life (QOL) among 3 groups of bowel preparations: no enema vs. sodium chloride enema vs. soap-suds enema (SSE). Materials and Method: Three hundred and thirty three women undergoing gynecological laparotomy surgery and without risks to bowel lumen entry between November 2014 and October 2015 were randomized to receive no enema (n = 111), sodium chloride enema (n = 111) or SSE (n = 111) for bowel preparation. Surgeons, who were blinded for the type of bowel preparation, assessed the surgical visualization and the efficacy of bowel packing. The patients' satisfaction and the QOL were also assessed on the days of admission, operation, post-operation, and discharge. Results: The patients' features of the 3 groups were well balanced. The surgeon's satisfaction was rated excellent as 56.8, 63.1 and 65.8% in the no-enema, sodium chloride and SSE groups (p = 0.830), respectively. The patients in the no-bowel-preparation group were satisfied more significantly than the other groups (p = 0.001). No significant differences in QOL were observed among the 3 groups. Conclusion: The type of bowel preparation for exploratory gynecologic surgery did not affect the surgical visualization and the QOL of the patients.

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Section: Methodsmentioning

confidence: 99%

Appropriate Bowel Preparation for Laparotomy Gynecologic Surgery: A Prospective, Surgeon-Blinded Randomized Study

Suadee

Suprasert²

2016

Gynecol Obstet Invest

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“…It is generally preferred for bowel preparation by adult surgeons [1,10] and gastroenterologists [31]. However, some adverse effects due to hyperphosphatemia and hypocalcemia have been reported during bowel cleansing [32], especially in pediatric patients [33] and chronic use for constipation [34].…”

Section: Discussionmentioning

confidence: 99%

“…During this time, it is also important to know how cathartic agents influence the colonic flora. There are many experimental and clinical studies evaluating the effects of WBI on colonic flora using different solutions [2,[10][11][12][13], or comparing the effects of WBI with TBC on colonic flora [14,15]. In addition, the efficacy of different methods of TBC have been evaluated in some clinical and experimental studies [16,17].…”

Section: Introductionmentioning

confidence: 99%

Effects of Hyperosmolar Agents – Lactulose, Lactitol, Sodium Phosphate and Polyethylene Glycol – on Cecal Coliform Bacteria during Traditional Bowel Cleansing: An Experimental Study in Rats

Demiroğullarι

Poyraz²,

Çırak

et al. 2004

Eur Surg Res

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Mechanical bowel cleansing is considered to be necessary prior to colorectal surgery, some radiological or endoscopic procedures, and for fecal disimpaction. Traditional bowel cleansing (TBC) with cathartics and enemas is a method of mechanical bowel cleansing for patients who have restrictive factors for whole-bowel irrigation (WBI), such as excessive fecal impaction, cardiac, hepatic or renal disorders. In this experimental study, TBC with hyperosmolar agents was evaluated in terms of their effects on colonic flora and bacterial translocation (BT). Sprague-Dawley rats were divided into 6 groups. The animals, except controls, were not fed for 72 h but received tap water ad libitum. During this period, lactulose, lactitol, sodium phosphate (NaP), polyethylene glycol 3350 (PEG3350) and physiological saline gavages were administered to the rats in groups 1–5, respectively, once a day. All animals except controls (group 6) received enemas with 15 ml of warm saline twice a day. The cecum, mesenteric lymph nodes (MLNs) and portal vein blood were sampled for microbiological and histopathological analysis. The highest level of coliform bacterial overgrowth and BT to MLNs were observed in the lactulose group, although the others, except the saline and control groups, also caused some degree of BT. Portal vein cultures were negative for all groups. Histopathological damage was not associated with cecal bacterial count and BT. As a result of this study, PEG3350 seems to be safer and more effective than lactulose, lactitol and NaP during TBC.

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“…Although both forms of preparation were found to be equally effective, sodium phosphate was better tolerated [2] . Similar results in terms of tolerability have been reported in an elderly population undergoing colonoscopy [3] .…”

Section: Introductionmentioning

confidence: 92%

Management of the Gastrointestinal Tract at the Time of Cystectomy

2006

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Radical cystectomy impacts on the gastro-intestinal tract in several ways. Clearly there is the need for bowel mobilisation, resection and anastamosis in order to create a urinary diversion, and the use of bowel preparation or antibiotics are controversial topics. Post-operatively ileus is common and there is debate about the routine use of NG tubes. Early enteral feeding is a modern concept but not yet proven. In the long-term there can be problems such as diarrhoea and B12 deficiency. All of these issues are discussed in this review using the latest available evidence.

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Mechanical Bowel Preparation for Elective Colorectal Surgery: A Prospective, Randomized, Surgeon-Blinded Trial Comparing Sodium Phosphate and Polyethylene Glycol-Based Oral Lavage Solutions

Cited by 46 publications

References 0 publications

Appropriate Bowel Preparation for Laparotomy Gynecologic Surgery: A Prospective, Surgeon-Blinded Randomized Study

Appropriate Bowel Preparation for Laparotomy Gynecologic Surgery: A Prospective, Surgeon-Blinded Randomized Study

Effects of Hyperosmolar Agents – Lactulose, Lactitol, Sodium Phosphate and Polyethylene Glycol – on Cecal Coliform Bacteria during Traditional Bowel Cleansing: An Experimental Study in Rats

Management of the Gastrointestinal Tract at the Time of Cystectomy

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