Mechanical Characteristics and Bioactivity of Nanocomposite Hydroxyapatite/Collagen Coated Titanium for Bone Tissue Engineering

Abstract

In the present study, we have analyzed the mechanical characteristics and bioactivity of titanium coating with hydroxyapatite/bovine collagen. Hydroxyapatite (HAp) was synthesized from a Pinctada maxima shell and has a stoichiometry (Ca/P) of 1.72 and a crystallinity of 92%, suitable for coating materials according to ISO and Food and Drug Administration (FDA) standards. Titanium (Ti) substrate coatings were fabricated at HAp concentrations of 1% (Ti/HAp-1) and 3% (Ti/HAp-3) and a bovine collagen concentration of 1% (Ti/HAp/Coll) by the electrophoresis deposition (EPD) method. The compressive strength of Ti/HAp-1 and Ti/HAp-3 was 87.28 and 86.19 MPa, respectively, and it increased significantly regarding the control/uncoated Ti (46.71 MPa). Furthermore, the Ti/HAp-coll (69.33 MPa) has lower compressive strength due to collagen substitution (1%). The bioactivity of Ti substrates after the immersion into simulated body fluids (SBF) for 3–10 days showed a high apatite growth (Ca2+ and PO43−), according to XRD, FTIR, and SEM-EDS results, significantly on the Ti/HAp-coll.

Construction of functional surfaces for dental implants to enhance osseointegration

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Recent progress of electrospun nanofibers as burning dressings

“…[26][27][28] For example, in the biomedical eld, electrospun nanobers are used in wound dressings, tissue engineering scaffolds, and drug delivery. [29][30][31][32][33] Electrospun nanober wound dressings have many outstanding advantages. Firstly, electrospun nanobers have a larger specic surface area, providing more adhesion and growth sites for cells.…”

Synthesis and Characterization of a Titanium-Based Functionally Graded Material-Structured Biocomposite using Powder Metallurgy

“…Bone is a vital organ, and it is considered among the most frequently transplanted tissues of the human body. There has been a lot of research going on in the field of biomaterials to find the right combination of materials that could exactly mimic the natural tissue response upon implantation, providing a successful regeneration of the damaged tissue . Biomaterials can be made from a wide range of materials, including metals, polymers, ceramics, and natural substances, such as bone and collagen .…”

“…There has been a lot of research going on in the field of biomaterials to find the right combination of materials that could exactly mimic the natural tissue response upon implantation, providing a successful regeneration of the damaged tissue. 1 Biomaterials can be made from a wide range of materials, including metals, polymers, ceramics, and natural substances, such as bone and collagen. 2 Some examples of materials used as bone implants are metallic implants, 3 of which the most common metals used are Fe, Ni, Cr, Mn, Ti, and their intermixed alloys.…”