Mechanical characteristics of BMSCs-intervened sciatic nerve in chronic alcohol-intoxicated animal model

Li, Peng; Chen, Yudong; Yang, Kun; Chen, Dachuan; Kong, Daliang

doi:10.1080/00207454.2020.1750397

“…El-Metwaly et al [ 45 ] found that MSCs increase GSH levels and reduce MDA levels in lung tissue of rats subjected to acute lung injury. Li et al [ 46 ] reported that MSCs can restore the levels of GSH and MDA in rats with chronic alcoholism, and its effects on repairing sciatic nerve were obvious. Liu et al [ 47 ] reported that MSCs significantly increase the activity of glutathione (GSH) and reduce the levels of MDA in rats induced by unilateral ureteral obstruction.…”

Section: Discussionmentioning

confidence: 99%

Nephroprotective Effect of Mesenchymal Stem Cell-Based Therapy of Kidney Disease Induced by Toxicants

Lin

¹

,

Lin

²

,

Liao

³

et al. 2020

Stem Cells International

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Background. Renal damage caused by drug toxicity is becoming increasingly common in the clinic. Preventing and treating kidney damage caused by drug toxicity are essential to maintain patient health and reduce the social and economic burden. In this study, we performed a meta-analysis to assess the nephroprotective effect of mesenchymal stem cells (MSCs) in the treatment of kidney disease induced by toxicants. Methods. The Cochrane Library, Embase, ISI Web of Science, and PubMed databases were searched up to December 31, 2019, to identify studies and extract data to assess the efficacy of MSCs treatment of kidney disease induced by toxicants using Cochrane Review Manager Version 5.3. A total of 27 studies were eligible and selected for this meta-analysis. Results. The results showed that a difference in serum creatinine levels between the MSC treatment group and control group was observed for 2, 4, 5, 6-8, 10-15, 28-30, and ≥42 days (2 days: WMD = − 0.88 , 95% CI: -1.34, -0.42, P = 0.0002 ; 4 days: WMD = − 0.74 , 95% CI: -0.95, -0.54, P < 0.00001 ; 5 days: WMD = − 0.46 , 95% CI: -0.67, -0.25, P < 0.0001 ; 6-8 days: WMD = − 0.55 , 95% CI: -0.84, -0.26, P = 0.0002 ; 10-15 days: WMD = − 0.37 , 95% CI: -0.53, -0.20, P < 0.0001 ; 28-30 days: WMD = − 0.53 , 95% CI: -1.04, -0.02, P = 0.04 ; ≥42 days: WMD = − 0.22 , 95% CI: -0.39, -0.06, P = 0.007 ). Furthermore, a difference in blood urea nitrogen levels between the MSC treatment group and control group was observed for 2-3, 4-5, 6-8, and ≥28 days. The results also indicate that MSC treatment alleviated inflammatory cells, necrotic tubules, regenerative tubules, and renal interstitial fibrosis in kidney disease induced by toxicants. Conclusion. MSCs may be a promising therapeutic agent for kidney disease induced by toxicants.

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“…El-Metwaly et al [40] found that MSCs can increase the GSH level and reduce the MDA level in lung tissue of acute lung injury rats. Zhang et al [41] reported that MSC effectively reduced the level of MDA, and increased SOD in the lung tissue of acute lung injury rats. Liu et al [42] reported that MSC significantly increased the activity of glutathione (GSH), and reduced the levels of MDA in rats induced by unilateral ureteral obstruction.…”

Section: Discussionmentioning

confidence: 99%

Nephroprotective effect of mesenchymal stem cells in therapy of kidney disease induced by toxicant

Zhou

¹

,

Lin

²

,

Liao

³

et al. 2020

Preprint

0

View full text Add to dashboard Cite

Background Renal damage caused by drug toxicity is becoming more and more common in clinic. How to avoid and treat kidney damage caused by drug toxicity is essential to maintain patient health and reduce social economic burden. In this study, we performed a meta-analysis to assess the nephroprotective effect of mesenchymal stem cells (MSCs) in therapy of kidney disease induced by toxicant. Methods Cochrane Library, Embase, ISI Web of Science and PubMed databases were searched up to Dec 31, 2019 to identify the studies and extract the data to assess the efficacy of MSCs for kidney disease induced by toxicant using Cochrane Review Manager Version 5.3. Results 27 studies were eligible and recruited for this meta-analysis. The results showed that the difference of Scr between MSCs treatment group and control group was notable for 2 days, 4 days, 5 days, 6-8 days, 10-15 days, ≥42 days (2 days: WMD =-0.88, 95%CI: -1.34, -0.42, P=0.0002; 4 days: WMD=-0.69, 95%CI: -0.99, -0.39, P<0.00001; 5 days: WMD=-0.46, 95%CI: -0.67, -0.25, P<0.0001; 6-8 days: WMD=-0.51, 95%CI: -0.79, -0.22, P=0.0005; 10-15 days: WMD =-0.38, 95%CI: -0.56, -0.20, P<0.0001; ≥42 days: WMD =-0.22, 95%CI: -0.39, -0.06, P=0.007). Furthermore, the difference of BUN between MSCs treatment group and control group was notable for 2-3 days, 4-5 days, 6-8 days, ≥28 days. The results also indicated that MSCs treatment can alleviate the inflammatory cells, necrotic tubule, regenerative tubules, renal interstitial fibrosis in kidney disease induced by toxicant. Conclusion: MSCs might be a promising therapeutic agent for kidney disease induced by toxicant.

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“…El-Metwaly et al [40] found that MSCs can increase the GSH level and reduce the MDA level in lung tissue of acute lung injury rats. Zhang et al [41] reported that MSC effectively reduced the level of MDA, and increased SOD in the lung tissue of acute lung injury rats. Liu et al [42] reported that MSC signi cantly increased the activity of glutathione (GSH), and reduced the levels of MDA in rats induced by unilateral ureteral obstruction.…”

Section: Discussionmentioning

confidence: 99%

Nephroprotective effect of mesenchymal stem cells in therapy of kidney disease induced by toxicant

Zhou

¹

,

Lin

²

,

Liao

³

et al. 2020

Preprint

0

View full text Add to dashboard Cite

Background Renal damage caused by drug toxicity is becoming more and more common in clinic. How to avoid and treat kidney damage caused by drug toxicity is essential to maintain patient health and reduce social economic burden. In this study, we performed a meta-analysis to assess the nephroprotective effect of mesenchymal stem cells (MSCs) in therapy of kidney disease induced by toxicant. Methods Cochrane Library, Embase, ISI Web of Science and PubMed databases were searched up to Dec 31, 2019 to identify the studies and extract the data to assess the efficacy of MSCs for kidney disease induced by toxicant using Cochrane Review Manager Version 5.3. Results 27 studies were eligible and recruited for this meta-analysis. The results showed that the difference of Scr between MSCs treatment group and control group was notable for 2 days, 4 days, 5 days, 6–8 days, 10–15 days, ≥ 42 days (2 days: WMD =-0.88, 95%CI: -1.34, -0.42, P = 0.0002; 4 days: WMD=-0.69, 95%CI: -0.99, -0.39, P < 0.00001; 5 days: WMD=-0.46, 95%CI: -0.67, -0.25, P < 0.0001; 6–8 days: WMD=-0.51, 95%CI: -0.79, -0.22, P = 0.0005; 10–15 days: WMD =-0.38, 95%CI: -0.56, -0.20, P < 0.0001; ≥42 days: WMD =-0.22, 95%CI: -0.39, -0.06, P = 0.007). Furthermore, the difference of BUN between MSCs treatment group and control group was notable for 2–3 days, 4–5 days, 6–8 days, ≥ 28 days. The results also indicated that MSCs treatment can alleviate the inflammatory cells, necrotic tubule, regenerative tubules, renal interstitial fibrosis in kidney disease induced by toxicant. Conclusion MSCs might be a promising therapeutic agent for kidney disease induced by toxicant.

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Mechanical characteristics of BMSCs-intervened sciatic nerve in chronic alcohol-intoxicated animal model

Cited by 3 publications

References 22 publications

Nephroprotective Effect of Mesenchymal Stem Cell-Based Therapy of Kidney Disease Induced by Toxicants

Nephroprotective Effect of Mesenchymal Stem Cell-Based Therapy of Kidney Disease Induced by Toxicants

Nephroprotective effect of mesenchymal stem cells in therapy of kidney disease induced by toxicant

Nephroprotective effect of mesenchymal stem cells in therapy of kidney disease induced by toxicant

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