Mechanical characteristics of the ureter and clinical implications

O’Meara, Sorcha; Cunnane, Eoghan M.; Croghan, Stefanie M.; Cunnane, Connor V.; Walsh, Michael T.; O’Brien, Fergal J.; Davis, Niall F.

doi:10.1038/s41585-023-00831-1

Cited by 4 publications

(1 citation statement)

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“…The purpose of this preliminary work was to test the mechanical response of native porcine ureteral tissue by performing a mechanical characterization, at both tissue and substructural levels, using ring tensile and membrane flexion tests, enriching the poor mechanical and morphological evaluations performed by others on ureters ( O’Meara et al, 2024 ). The ring tensile set-up permitted the avoidance of invasive sample cutting, as performed in the standard uniaxial tensile test, preserving the circular nature of the ureter, which functions as a conduit.…”

Section: Introductionmentioning

confidence: 99%

Mechanical characterization of porcine ureter for the evaluation of tissue-engineering applications

Casarin,

Toniolo,

Todesco

et al. 2024

Front. Bioeng. Biotechnol.

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Introduction: Clinics increasingly require readily deployable tubular substitutes to restore the functionality of structures like ureters and blood vessels. Despite extensive exploration of various materials, both synthetic and biological, the optimal solution remains elusive. Drawing on abundant literature experiences, there is a pressing demand for a substitute that not only emulates native tissue by providing requisite signals and growth factors but also exhibits appropriate mechanical resilience and behaviour.Methods: This study aims to assess the potential of porcine ureters by characterizing their biomechanical properties in their native configuration through ring and membrane flexion tests. In order to assess the tissue morphology before and after mechanical tests and the eventual alteration of tissue microstructure that would be inserted in material constitutive description, histological staining was performed on samples. Corresponding computational analyses were performed to mimic the experimental campaign to identify the constitutive material parameters.Results: The absence of any damages to muscle and collagen fibres, which only compacted after mechanical tests, was demonstrated. The experimental tests (ring and membrane flexion tests) showed non-linearity for material and geometry and the viscoelastic behaviour of the native porcine ureter. Computational models were descriptive of the mechanical behaviour ureteral tissue, and the material model feasible.Discussion: This analysis will be useful for future comparison with decellularized tissue for the evaluation of the aggression of cell removal and its effect on microstructure. The computational model could lay the basis for a reliable tool for the prediction of solicitation in the case of tubular substitutions in subsequent simulations.

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Section: Introductionmentioning

confidence: 99%