Mechanical Characterization of Additive Manufactured Polymeric Scaffolds for Tissue Engineering

Pecorini, Gianni; Chiellini, Federica; Puppi, Dario

doi:10.1007/978-981-16-4566-2_5

Cited by 5 publications

(5 citation statements)

References 213 publications

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“…Different published articles have reported that the tensile modulus and strength of MEX-manufactured PLA samples (1–4 GPa and 15–75 MPa, respectively) are comparable to those of PLA films made by solvent casting or compression molding [ 45 , 46 , 47 ]. In particular, Chacón et al [ 48 ] recently demonstrated that the tensile and three-point bending properties of PLA can be significantly tuned by acting on build orientation, layer thickness, and feed rate.…”

Section: Resultsmentioning

confidence: 96%

Additive Manufacturing of Anatomical Poly(d,l-lactide) Scaffolds

2022

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Poly(lactide) (PLA) is one of the most investigated semicrystalline polymers for material extrusion (MEX) additive manufacturing (AM) techniques based on polymer melt processing. Research on its application for the development of customized devices tailored to specific anatomical parts of the human body can provide new personalized medicine strategies. This research activity was aimed at testing a new multifunctional AM system for the design and fabrication by MEX of anatomical and dog-bone-shaped PLA samples with different infill densities and deposition angles. In particular, a commercial PLA filament was employed to validate the computer-aided design (CAD) and manufacturing (CAM) process for the development of scaffold prototypes modeled on a human bone defect. Physical-chemical characterization of the obtained samples by 1H-NMR spectroscopy, size exclusion chromatography (SEC), thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC) demonstrated a small reduction of polymer molecular weight (~5%) due to thermal processing, as well as that the commercial polymer employed was a semicrystalline poly(d,l-lactide). Mechanical characterization highlighted the possibility of tuning elastic modulus and strength, as well as the elongation at break up to a 60% value by varying infill parameters.

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Section: Resultsmentioning

confidence: 96%

Additive Manufacturing of Anatomical Poly(d,l-lactide) Scaffolds

2022

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“…This stress‐strain profile was previously described for other additively manufactured amorphous polymers and related to the rearrangement of the porous macrostructure, as well as to macromolecules drawing and straightening along the direction of the applied force. [ 15,30 ]…”

Section: Resultsmentioning

confidence: 99%

“…This stress-strain profile was previously described for other additively manufactured amorphous polymers and related to the rearrangement of the porous macrostructure, as well as to macromolecules drawing and straightening along the direction of the applied force. [15,30] When tested under compression, PMMA-FFF samples showed a first linear region followed by a progressive increase of curve slope until the load cell limit was reached for a strain value of ≈30%. In the case of PMMA-CAWS, the samples showed a typical three-phase curve related to an initial elastic response of the fiber-fiber contact points, followed by a plateau due to pores collapse and a final stress increase as a consequence of polymer matrix densification.…”

Section: Mechanical Characterizationmentioning

confidence: 99%

Melt‐Versus Solution‐Extrusion Additive Manufacturing of Poly(methyl methacrylate) Medical Implant Prototypes

Puppi,

Braccini,

Corti

et al. 2023

Macro Chemistry & Physics

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The development of tailored additive manufacturing (AM) approaches is resulting in novel strategies for engineering the macro/microstructural details of potential medical devices made of biocompatible polymers. The aim of this work is the employment of a multifunctional AM machine for fabricating poly(methyl methacrylate) (PMMA) constructs with a predefined shape and porous architecture, by either melt‐ or solution‐extrusion AM. In particular, PMMA porous scaffolds are manufactured by employing fused filament fabrication (FFF) or computer‐aided wet‐spinning (CAWS). The comparative characterization of the two developed PMMA implant prototypes demonstrates significant differences in terms of porous structure, polymer surface topography, material composition, glass transition temperature, and mechanical properties. As a consequence, FFF‐printed PMMA samples support a faster in vitro proliferation of a murine fibroblast cell line in comparison to PMMA scaffolds by CAWS. The results achieved encourage further research on the developed processing protocols, aimed at the development of tailored PMMA implants for personalized surgery applications.

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“…Additive manufacturing techniques are based on computer-aided design and manufacturing of 3D objects layer-by-layer through different approaches (e.g., melt- or solution-extrusion). They allow the fabrication of scaffolds with customized shapes and dimensions, as well as the architecture of their porous structure [ 57 ].…”

Section: Polymeric Systems For Controlled Drug Releasementioning

confidence: 99%

Polymeric Systems for the Controlled Release of Flavonoids

2023

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Flavonoids are natural compounds that are attracting great interest in the biomedical field thanks to the wide spectrum of their biological properties. Their employment as anticancer, anti-inflammatory, and antidiabetic drugs, as well as for many other pharmacological applications, is extensively investigated. One of the most successful ways to increase their therapeutic efficacy is to encapsulate them into a polymeric matrix in order to control their concentration in the physiological fluids for a prolonged time. The aim of this article is to provide an updated overview of scientific literature on the polymeric systems developed so far for the controlled release of flavonoids. The different classes of flavonoids are described together with the polymers most commonly employed for drug delivery applications. Representative drug delivery systems are discussed, highlighting the most common techniques for their preparation. The flavonoids investigated for polymer system encapsulation are then presented with their main source of extraction and biological properties. Relevant literature on their employment in this context is reviewed in relationship to the targeted pharmacological and biomedical applications.

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Mechanical Characterization of Additive Manufactured Polymeric Scaffolds for Tissue Engineering

Cited by 5 publications

References 213 publications

Additive Manufacturing of Anatomical Poly(d,l-lactide) Scaffolds

Additive Manufacturing of Anatomical Poly(d,l-lactide) Scaffolds

Melt‐Versus Solution‐Extrusion Additive Manufacturing of Poly(methyl methacrylate) Medical Implant Prototypes

Polymeric Systems for the Controlled Release of Flavonoids

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