Mechanical characterization of PVA hydrogels’ rate-dependent response using multi-axial loading

Nafo, Wanis; Al-Mayah, Adil

doi:10.1371/journal.pone.0233021

Cited by 11 publications

(3 citation statements)

References 46 publications

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“…Polyvinyl alcohol (PVA) is a widely used polymer with good thermal stability, biocompatibility, biodegradability, mechanical strength, viscoelasticity, and hydrophilicity [ 67 , 111 ]. It is non-toxic, pH stable, and has coagulating ability; it is thus suitable for cell growth but limited by its inability to control fast-flowing haemorrhages [ 86 ].…”

Section: Polymers and Cross-linking Agentsmentioning

confidence: 99%

A Comprehensive Review of Cross-Linked Gels as Vehicles for Drug Delivery to Treat Central Nervous System Disorders

Mashabela

Maboa

Miya

et al. 2022

Gels

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Gels are attractive candidates for drug delivery because they are easily producible while offering sustained and/or controlled drug release through various mechanisms by releasing the therapeutic agent at the site of action or absorption. Gels can be classified based on various characteristics including the nature of solvents used during preparation and the method of cross-linking. The development of novel gel systems for local or systemic drug delivery in a sustained, controlled, and targetable manner has been at the epitome of recent advances in drug delivery systems. Cross-linked gels can be modified by altering their polymer composition and content for pharmaceutical and biomedical applications. These modifications have resulted in the development of stimuli-responsive and functionalized dosage forms that offer many advantages for effective dosing of drugs for Central Nervous System (CNS) conditions. In this review, the literature concerning recent advances in cross-linked gels for drug delivery to the CNS are explored. Injectable and non-injectable formulations intended for the treatment of diseases of the CNS together with the impact of recent advances in cross-linked gels on studies involving CNS drug delivery are discussed.

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Section: Polymers and Cross-linking Agentsmentioning

confidence: 99%

A Comprehensive Review of Cross-Linked Gels as Vehicles for Drug Delivery to Treat Central Nervous System Disorders

Mashabela

Maboa

Miya

et al. 2022

Gels

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“…From the mechanical perspective, the concentration of the polymer network in hydrogels controls, to large extent, their mechanical strength allowing them to mimic the mechanics of physiologically loaded tissues [4]. Consequently, due to their availability and relatively low cost, hydrogels have become an attractive option when developing quantitative techniques that measure the mechanics of biological tissues [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Hydrogel Biomaterials for Drug Delivery: Mechanisms, Design, and Drugs

Nafo¹

2023

Hydrogels - From Tradition to Innovative Platforms With Multiple Applications

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Due to their unique physical and chemical properties, hydrogels have attracted significant attention in several medical fields, specifically, drug delivery applications in which gel-based nanocarriers deliver drug molecules to the region of interest in biological organs. For different drug delivery applications, hydrogel systems can be manipulated to provide passive and/or active delivery. Thus, several drug targeting, loading, and releasing mechanisms have been devised and reported in the literature. This chapter discusses these mechanisms and their efficacy with respect to different drug delivery applications. Furthermore, the drug dosage is dependent on the design and shape of the hydrogel systems, which in turn depend on the route of the drug administration. This chapter covers the types of hydrogel-based products applied via different routes of drug administration. Lastly, this chapter addresses different classifications of delivered drugs including small molecular weight drugs; therapeutic proteins and peptides; and vaccines.

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“…Liposomes were also found to have no negative effects on hydrogel formation. Hydrogels based on poly(vinyl alcohol) (PVA) with absorbing features such as good viscoelastic properties 28 , biocompatibility 29 , biodegradability 30 and high hydrophilicity 31 have been used in a wide range of biomedical applications, especially in producing wound dressings [32][33][34] . However, pure PVA hydrogel exhibits a weak tensile strength and an insu cient capacity of swelling, limiting its application as a wound dressing 35 .…”

Section: Introductionmentioning

confidence: 99%

Liposomal Nanocarriers-Loaded Poly(vinyl alcohol) (PVA)/Poly(ethylene glycol) (PEG) Hydrogels: Physico-mechanical Properties and Drug Release

Jafari Jezeh,

Entezam,

Haghiralsadat

et al. 2023

J Polym Environ

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The main objective of this research is to investigate how curcumin liposomal nanocarriers in uence the drug release behaviour of PVA/PEG hydrogels in relation to physico-mechanical properties. For this purpose, optimal nanoliposomes from drug loading and release viewpoints, prepared by the thin-lm hydration method, were incorporated into the hydrogel composition. Hydrogel samples were physically crosslinked using the freeze-thaw procedure. According to the atomic force microscopy and eldemission scanning electron microscopy observations, nanoliposomes showed a spherical morphology with an average particle size of 100 nm and narrow size distribution. The X-ray diffraction results revealed that adding nanoliposomes to the hydrogel increases the degree of PVA chains crystallinity, enhances tensile modulus and tensile strength of the hydrogel, while decreasing swelling and dehydration rates. SEM micrographs observation displayed that the porosity in the hydrogel structure in the presence of nanoliposomes increases. Nevertheless, in agreement with physical properties, drug release from nanoliposome-in-hydrogel is slower and more controlled as compared to that from free curcumin hydrogel, especially in the early stages. The MTT assay results indicated that although all hydrogel samples are non-toxic, human foreskin broblast cell proliferation on hydrogel in the presence of curcumin-loaded nanoliposomes has improved somewhat.

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Mechanical characterization of PVA hydrogels’ rate-dependent response using multi-axial loading

Cited by 11 publications

References 46 publications

A Comprehensive Review of Cross-Linked Gels as Vehicles for Drug Delivery to Treat Central Nervous System Disorders

A Comprehensive Review of Cross-Linked Gels as Vehicles for Drug Delivery to Treat Central Nervous System Disorders

Hydrogel Biomaterials for Drug Delivery: Mechanisms, Design, and Drugs

Liposomal Nanocarriers-Loaded Poly(vinyl alcohol) (PVA)/Poly(ethylene glycol) (PEG) Hydrogels: Physico-mechanical Properties and Drug Release

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