Mechanical Characterization of Vocal Fold Tissue: A Review Study

Miri, Amir K.

doi:10.1016/j.jvoice.2014.03.001

Cited by 87 publications

(111 citation statements)

References 75 publications

(80 reference statements)

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“…Pig larynges may be more ideal ex vivo models due to increased homology to human vocal fold cover thickness, structure, and overall stiffness[14]. The collagen, elastin, and hyaluronic acid content varies subtly between human and pigs [15]. Testing extends to human samples as well [16, 17].…”

Section: Biomechanical Testing Overviewmentioning

confidence: 99%

Functional assessment of the ex vivo vocal folds through biomechanical testing: A review

Dion

Jeswani

Roof

et al. 2016

Materials Science and Engineering: C

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The human vocal folds are complex structures made up of distinct layers that vary in cellular and extracellular composition. The mechanical properties of vocal fold tissue are fundamental to the study of both the acoustics and biomechanics of voice production. To date, quantitative methods have been applied to characterize the vocal fold tissue in both normal and pathologic conditions. This review describes, summarizes, and discusses the most commonly employed methods for vocal fold biomechanical testing. Force-elongation, torsional parallel plate rheometry, simple-shear parallel plate rheometry, linear skin rheometry, and indentation are the most frequently employed biomechanical tests for vocal fold tissues and each provide material properties data that can be used to compare native tissue verses diseased for treated tissue. Force-elongation testing is clinically useful, as it allows for functional unit testing, while rheometry provides physiologically relevant shear data, and nanoindentation permits micrometer scale testing across different areas of the vocal fold as well as whole organ testing. Thoughtful selection of the testing technique during experimental design to evaluate a hypothesis is important to optimizing biomechanical testing of vocal fold tissues.

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Section: Biomechanical Testing Overviewmentioning

confidence: 99%

Functional assessment of the ex vivo vocal folds through biomechanical testing: A review

Dion

Jeswani

Roof

et al. 2016

Materials Science and Engineering: C

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“…Large elastic moduli were obtained in comparison with the previously published data obtained using parallel-plate rheometers (Chan and Titze 1999, Kelleher et al 2010). The greater values of modulus obtained in the current study may be partly due to the anisotropic properties of the vocal fold tissue (Miri 2014). It has been previously shown that the longitudinal elastic modulus of vocal fold tissue is at least one order of magnitude greater than the transverse elastic modulus (Heris et al 2013, Miri et al 2013).…”

Section: Resultsmentioning

confidence: 67%

Determination of the elastic properties of rabbit vocal fold tissue using uniaxial tensile testing and a tailored finite element model

Latifi

Miri

Mongeau

2014

Journal of the Mechanical Behavior of Biomedical Materials

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The aim of the present study was to quantify the effects of the specimen shape on the accuracy of mechanical properties determined from a shape-specific model generation strategy. Digital images of five rabbit vocal folds (VFs) in their initial undeformed conditions were used to build corresponding specific solid models. The displacement field of the VFs under uniaxial tensile test was then measured over the visible portion of the surface using digital image correlation. A three-dimensional finite element model was built, using ABAQUS, for each solid model, while imposing measured boundary conditions. An inverse-problem method was used, assuming a homogeneous isotropic linear elastic constitutive model. Unknown elastic properties were identified iteratively through an error minimization technique between simulated and measured force-time data. The longitudinal elastic moduli of the five rabbit VFs were calculated and compared to values from a simple analytical method and those obtained by approximating the cross-section as elliptical. The use of shape-specific models significantly reduced the standard deviation of the Young's modulus of the tested specimens. However, a non-parametric statistical analysis test, i.e., the Friedman test, yielded no statistically significant differences between the shape-specific method and the elliptic cylindrical finite element model. Considering the required procedures to reconstruct the shape-specific finite element model for each tissue specimen, it might be expedient to use the simpler method when large numbers of tissue specimens are to be compared regarding their Young's moduli.

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“…The variation of the elastic modulus along the anterior-posterior direction has been investigated for vocal fold tissue 3, 9 . For example, the indentation moduli displayed a positive gradient from the center toward the anterior direction.…”

Section: Discussion and Concluding Remarksmentioning

confidence: 99%

“…Computational simulations, such as finite element models 1, 2 , have been used to assess stresses and strains within vocal folds undergoing idealized mechanical vibrations. Conventional mechanical testing methods have been implemented to characterize the elastic properties of vocal fold tissue 3 . However, its fracture toughness has not yet been investigated.…”

Section: Introductionmentioning

confidence: 99%

Fracture Toughness of Vocal Fold Tissue: A Preliminary Study

et al. 2016

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A customized mechanical tester that slices thin, soft samples was utilized to measure fracture toughness of vocal fold tissue. Porcine vocal fold lamina propria was subjected to quasi-static, guillotine-like tests at three equally distanced regions along the anterior-posterior direction. The central one-third where high-velocity collisions between vocal folds occur was found to have the maximum fracture toughness. In contrast, the anterior one-third featured a lower toughness. Fracture toughness can be indicative of the risk of benign and malignant lesions in vocal fold tissue.

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Mechanical Characterization of Vocal Fold Tissue: A Review Study

Cited by 87 publications

References 75 publications

Functional assessment of the ex vivo vocal folds through biomechanical testing: A review

Functional assessment of the ex vivo vocal folds through biomechanical testing: A review

Determination of the elastic properties of rabbit vocal fold tissue using uniaxial tensile testing and a tailored finite element model

Fracture Toughness of Vocal Fold Tissue: A Preliminary Study

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